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Kidney Week

Abstract: TH-PO061

Clinical Significance of Hypoalbuminemia for AKI in Patients with Scrub Typhus

Session Information

Category: Acute Kidney Injury

  • 101 AKI: Epidemiology, Risk Factors, and Prevention

Authors

  • Oh, Ju hwan, Presbyterian Medical Center, Jeonju, Korea, Jeonju, Korea (the Republic of)
  • Sun, In O, Presbyterian Medical Center, Jeonju, Korea, Jeonju, Korea (the Republic of)
Background

The aim of this study is to investigate the clinical significance of hypoalbuminemia (HA) for acute kidney injury (AKI) in patients with scrub typhus.

Methods

From 2010 to 2017, 449 patients were diagnosed with scrub typhus. We divided the patients into two groups [normoalbuminemia (NA) vs. hypoalbuminemia (HA)] based on the serum albumin level of 3.5 g/dL, and compared the incidence, clinical characteristics, and severity of AKI based on RIFLE classification between two groups.

Results

Of the total 449 patients, 52 (11.6%) were categrized as HA group. Compared with patients in NA group, patients in HA group were older (74 ± 8 vs. 63 ± 13, P<0.01) and had higher total leukocyte counts (10.4 × 103/ mL vs. 6.9 × 103/mL, P<0.01). HA group showed significantly longer hospital stay (10.1 ± 4.7 vs 8.8 ± 4.5, p<0.01) and higher incidence of acute kidney injury (56% vs. 19%, p<0.01). The overall incidence of AKI was 22.9%; of which, 12.2%, 10.0% and 0.7% were classified as Risk, Injury and Failure, respectively. In a multivariate logistic regression analysis for predciting AKI, age, presence of chronic kidney disease, leukocytosis and hypoalbuminemia were significant predictors of AKI. Most patients recovered baseline renal function without renal replacement therapy following antibiotics therapy and supportive care.

Conclusion

Hypoabluminemia was closely associated with AKI in patients with scrub typhus.