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Kidney Week

Abstract: FR-PO425

Cognitive Impairment and Mortality in Maintenance Hemodialysis (HD) Patients: A Longitudinal Study

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis


  • Miyazaki, Sayaka, Nagasaki Kidney Center , Nagasaki, Japan
  • Funakoshi, Satoshi, Nagasaki Renal Center, Nagasaki, Japan
  • Ide, Mashumi, Nagasaki Kidney Center , Nagasaki, Japan
  • Hashiguchi, Jyunichiro, Nagasaki Kidney Center , Nagasaki, Japan
  • Sawase, Kenji, Nagasaki Kidney Center , Nagasaki, Japan
  • Kawazu, Tayo, Nagasaki Kidney Center, Nagasaki, Japan
  • Kubara, Takuya, Nagasaki Kidney Center, Nagasaki, Japan
  • Nishino, Tomoya, Nagasaki University School of Medicine, Nagasaki, NAGASAKI, Japan
  • Harada, Takashi, Nagasaki Kidney Center, Nagasaki, Japan
  • Hayashida, Masatoshi, Nagasaki Renal Center, Nagasaki, Japan

We examined the transition of the Mini-Mental State Examination (MMSE) results and the mortality rate of maintenance HD patients in our hospital over a 130-week period, in order to compare the cognitive functions and mortality.


Using the longitudinal cohort of 181 HD patients aged ≥65, we examined the MMSE in March 2016, and a follow-up MMSE was conducted on 112 surviving patients in September 2018. We also tracked the serological data during this period. MMSE score of 28 to 30 was classified as the normal group, 24 to 27 as mild cognitive impairment (MCI) group, and less than 23 as dementia group.


In 2016, 76 patients were within the normal group(41.9%, mean age 72.1), 48 were within the MCI group(26.5%, mean age 77.9), and 57 were within the dementia group(31.5%, mean age 80.2). As shown in figure 1 below, compared to the normal group, mortality rate decreased significantly as the severity of dementia further deteriorated. There was no significant difference in the nutritional status index such as albumin or Cholinesterase among these groups. The pneumonia-associated death in patients with dementia was twice as high as among those without dementia or MCI (64% vs 36%, 39%; p < 0.05).


This longitudinal study indicated that the presence of dementia is an independent predictor of mortality in patients on HD.


  • Private Foundation Support