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Abstract: SA-PO556

Prevalence and Risk Factor Analysis of Microalbuminuria in Type 2 Diabetic Patients: Data from Nationwide Registry of Primary Care Cohort of Thailand

Session Information

Category: Diabetic Kidney Disease

  • 602 Diabetic Kidney Disease: Clinical

Authors

  • Rattanasompattikul, Manoch, Golden Jubilee Medical Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Nakhon Pathom, Thailand
  • Raksasuk, Sukit, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
  • Rongkiettechakorn, Nuttawut, Golden Jubilee Medical Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Nakhon Pathom, Thailand
  • Promkan, Moltira, Faculty of Medical Technology, Mahidol University, Salaya, Phutthamonthon, Thailand
  • Masoodi, Sumana, Faculty of Medical Technology, Mahidol University, Salaya, Phutthamonthon, Thailand
  • Ngerninta, Kanyaphak, Golden Jubilee Medical Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Nakhon Pathom, Thailand
  • Supokawej, Aungkura, Faculty of Medical Technology, Mahidol University, Salaya, Phutthamonthon, Thailand
Background

Microalbuminuria (MAU), an indicator of glomerular injury, is associated with an increased risk of progressive renal deterioration, cardiovascular disease, and mortality. However, the prevalence of MAU in Asian populations is unclear, especially during various stages of chronic kidney disease (CKD). Thus, we examined the prevalence of microalbuminuria and its associated risk factors in Asian patients with type 2 diabetes mellitus (T2DM).

Methods

This study evaluated patients between 18 and 85 years old from the most extensive National Health Security System (NHS) of Thailand from 2011 to 2014. Multivariate regression analyses, including linear and logistic regression, were performed to assess the association between MAU and risk factors.

Results

A total of 7,587 T2DM patients were included. Sixty-four percent were female. The mean age was 63 ±11 years old. The prevalence of MAU was presented by percentage and 95% confidence interval (CI): CKD stage G1 32% (30–34); stage G2 34% (32–35); stage G3a 41% (39–44); stage G3b 47% (43–50); stage G4 70% (63–77); and stage G5 73% (60–82) (Figure1). The multivariate analysis identified the odds ratio (OR) of time-average systolic blood pressure (adjusted OR; 95% CI; P-value) as an independent risk factor for MAU presence. After adjusting for age, gender, body mass index, occupation, provinces, religions, categories of cholesterol, and % glycosylated hemoglobin, the resulting levels were 1.12; 0.94–1.32; 0.20 (<120 mm Hg group), reference group (120–140 mm Hg group), 1.21;1.07–1.36; 0.003 (140–160 mm Hg group), and 1.45; 1.21–1.75; <0.0001 (>160 mm Hg group).

Conclusion

Several factors demonstrated independent correlations with MAU in Asian populations. Higher time-average systolic blood pressure was associated with MAU, which may lead to further target organ damage in T2DM. MAU has also been observed to be much more prevalent in later CKD stages.

Figure1

Funding

  • Government Support - Non-U.S.