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Kidney Week

Abstract: TH-PO753

Serum Cystatin C Levels at Birth in Very-Low-Birth-Weight Infants

Session Information

  • Pediatric CKD
    November 07, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: Pediatric Nephrology

  • 1700 Pediatric Nephrology

Author

  • Sawada, Mariko, Kurashiki Central Hospital, Kurashiki, Japan
Background

Serum Cystatin C (CysC) is commonly used as a marker of glomerular filtration rates in children and adults. Although the reference intervals (RIs) of serum CysC has been well investigated, few reports demonstrated serum CysC levels in premature infants. The aim of this study was to investigate the RIs of serum CysC levels at birth in premature infants.

Methods

Eighty very low birth weight (VLBW, birth weight less than 1,500 g) infants admitted to our NICU between January 2018 and May 2019 were included, except for neonates with congenital anomalies of the kidney and urinary tract. Clinical data and serum CysC at birth were retrospectively collected from their medical records. All serum CysC concentrations were analyzed using a latex immunoturbidimetric assay. The RIs was defined as the set of CysC values 95% of these population.

Results

Data of 69 VLBW infants were available for this study. The CysC levels of 66 cases were distributed within 95% of these population. The gestational age was 29.2±3.1 weeks, and the birth weight was 1,061±290 g. It was included 27 (40.9%) male infants. The RIs of serum CysC levels at birth was 1.58±0.21 mg/L. Serum CysC levels in male infants were significantly higher than that in female infants (1.59 vs. 1.53 mg/L, p< 0.05). Serum CysC levels at birth did not related to gestational age, birth weight, and APGAR score. There was no difference between serum CysC levels in small-for-gestational age (SGA) and that in non-SGA infants.

Conclusion

The RIs of serum CysC levels at birth is higher than that in later life. Unlike serum creatinine, serum CysC concentrations are not affected by their mothers’ kidney function, therefore serum CysC levels might be a useful marker to evaluate the kidney function of neonates at birth.