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Abstract: FR-PO1053

The Relationship Between Retinal Artery Wall-to-Lumen Ratio and Kidney Pathology Findings in Accelerated Hypertension

Session Information

Category: Hypertension and CVD

  • 1402 Hypertension and CVD: Clinical, Outcomes, and Trials

Authors

  • De nattes, Tristan, Hôpital Tenon, APHP, Paris, France, Paris, France
  • Verney, Charles, APHP paris, Saint Ouen, France
  • Luque, Yosu, Assistance Publique - Hopitaux de Paris, Paris, France
  • Buob, David, Tenon Hospital and Sorbonne University, Paris, France
  • Paques, Michel, Quinze-Vingts Hospital, PAris, France
  • Rafat, Cedric, Hôpital Tenon, AP-HP, PARIS 20, France
Background

Accelerated hypertension is characterized by macrovascular and microvascular endothelial damage. In this study we analyze the relationship between retinal artery wall-to-lumen ratio (WLR) and renal histology.

Methods

All patients hospitalized into Kidney Intensive Care Unit for malignant hypertension with acute kidney injury had measurement of retinal wall-to-lumen ratio (WLR) using SPECTRALIS retina imaging. Renal clinical and pathology findings were collected as well as details pertaining to heart echography. Data were presented as median [25th-75th], correlation were calculated according to Spearman’s test.

Results

Twenty-seven patients were hospitalized for accelerated hypertension in our center between September 2016 and April 2019. Median age was 39.4 years old [30.7-45.3]. Initial systolic, diastolic and mean arterial pressure were 218 [185-239], 128 [113-162] and 153 [137-187] mmHg, respectively. Ten (37.0%) patients underwent haemodialysis during their stay, 8 (29.6%) patients underwent chronic haemodialysis, 4 (14.8%) had myocardial microvasculature involvement, 4 (14.8%) had posterior-reversible encephalopathy syndrome. Seventeen patients (63.0%) had kidney biopsy. Retinal WLR was correlated with systolic and mean arterial pressure, respectively r=0.56 (p=0.003) and r=0.46 (p=0.02), but did not reach significance for tubulo-interstitial fibrosis (r=-0.45, p=0.09) or glomerulosclerosis (r=-0.38, p=0.15). Retinal WLR was not correlated with renal WLR (r=0.13, p=0.6). Retinal WLR did not correlate with left ventricular mass estimation (r=0.10, p=0.6)

Conclusion

Retinal WLR was found to be closely correlated to initial systolic and mean arterial pressure. Perhaps due to the cohort size, we failed to demonstrate an association between retinal WLR and kidney pathology findings.