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Kidney Week

Abstract: TH-PO431

Urinary Calprotectin, Neutrophil Gelatinase Associated Lipocalin (NGAL), and KIM-1 in the Differentiation of Inflammatory vs. Noninflammatory CKD

Session Information

Category: CKD (Non-Dialysis)

  • 2102 CKD (Non-Dialysis): Clinical, Outcomes, and Trials

Authors

  • Seibert, Felix S., University Hospital Marien Hospital Herne, Herne, Germany
  • Westhoff, Timm H., University Hospital Marien Hospital Herne, Herne, Germany
Background

It has been demonstrated that urinary neutrophil gelatinase-associated lipocalin (NGAL) and calprotectin are helpful biomarkers in the differentiation of intrinsic and prerenal acute kidney injury. The present cross-sectional study investigates, whether urinary biomarkers are able to differentiate primarily inflammatory from non-inflammatory entities in chronic kidney disease (CKD).

Methods

Urinary calprotectin, NGAL and kidney injury molecule-1 (KIM-1) concentrations were assessed in a study population of 143 patients with stable CKD and 29 healthy controls. Stable renal function was defined as an eGFR fluctuation 5ml/min/1.73m2 in the past 12 months. Pyuria, metastatic carcinoma and renal transplantation were regarded as exclusion criteria. Diabetic nephropathy, hypertensive nephropathy, and polycystic kidney disease were categorized as “non-inflammatory renal diseases”, whereas glomerulonephritis and vasculitis were regarded as “inflammatory renal diseases”.

Results

Urinary calprotectin and NGAL concentrations significantly differed between CKD and healthy controls (p<0.05 each), whereas KIM-1 concentrations did not (p=0.84). Urinary calprotectin concentrations were numerically highest in glomerulonephritis/vasculitis (155.7 ng/ml), NGAL concentrations in diabetic and hypertensive nephropathy (18741 pg/ml), and KIM-1 concentrations in polycystic kidney disease (1556 pg/ml). However, the three biomarkers did neither show significant differences in-between the individual entities, nor the two categories of inflammatory vs. non-inflammatory renal diseases (calprotectin 155.7 vs. 96.99 ng/ml; NGAL 14896 vs. 11977 pg/ml; KIM-1 1388 vs. 1009 ng/ml; p>0.05 each).

Conclusion

The urinary biomarkers calprotectin, NGAL and KIM-1 have no diagnostic value in the differentiation of inflammatory vs. non-inflammatory etiologies of CKD.