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Abstract: TH-PO304

The Associations of Serum Uric Acid and All-Cause Mortality in Peritoneal Dialysis Patients

Session Information

Category: Dialysis

  • 703 Dialysis: Peritoneal Dialysis

Author

  • Qiu, Shanfang, The first affiliated hospital of xiamen university, Xiamen, China
Background

The relationship between serum uric acid and prognosis in diabetic peritoneal dialysis (PD) patients is unclear.This study was investigate whether baseline uric acid (UA) is an independent predictor of all-cause mortality in chronic renal failure patients (CRF) with peritoneal dialysis (PD)

Methods

A retrospective cohort study was designed. A total of 140 patients onstable continuous ambulatory peritoneal dialysis (CAPD) treatment for more than 3 months were collected and follow up at First affiliated hospital of Xiamen University Peritoneal Dialysis Center during the January 1st,2001 to the December 31st,2017. All demographic and laboratory data were recorded at baseline. The subjects were divided into three groups based on the tertile of UA valu（M1:UA＜387umol/L，M2:UA387～519umol/L，M3:UA ＞519umol/L）.Multivariate Cox regression and Kaplan-Meier method was used to calculate the hazard ratio (HR) of all-cause mortality.

Results

A total of 140 CAPD patients were enrolled in this study, including 63 cases of male (45%),77 cases of female (55%). The average age was 57 (range: 44-65) years. The median follow-up time was 31.9 (IQR:19.6，66.0)months. The average UA of all participants was 450.1±146.1 umol/L. No significant differences of baseline characteristics between patients with Age, sex ratio, body mass index, duration of dialysis, proportion of patients with hypertension, diabetes mellitus and cardiovascular diseases. Compared to M1 group, the levels of serum creatinine, urea nitrogen, blood phosphorus and blood potassium were higher in M3 group (P < 0.05). Univariate COX regression analysis suggested a positive correlation between all-cause mortality and baseline uric acid (UA HR=1.04,95%CI: 1.00-1.08, P=0.048). Multivariate COX regression analysis showed that increased baseline UA was an independent risk factor for all-cause mortality in PD patients(HR=1.04, 95%CI: 1.00-1.09, p=0.032).

Conclusion

UA was positively correlated with all-cause mortality in patients undergoing maintenance peritoneal dialysis. The increase of baseline UA elevation was an independent risk factor for all-cause mortality in those patients. Thecontrol of UA level may be helpful to prolong the survival time of patients with Peritoneal Dialysis.

Funding

  • Clinical Revenue Support