Abstract: SA-PO779
Insignificant Renal Artery Stenosis Is Associated with a Decrease in Renal Perfusion and Function
Session Information
- CKD: Mechanisms - III
November 09, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2103 CKD (Non-Dialysis): Mechanisms
Authors
- Lubas, Arkadiusz, Military Institute of Medicine, Warsaw, Poland
- Niemczyk, Stanislaw, Military Institute of Medicine, Warsaw, Poland
Background
Renal artery stenosis (RAS) exceeding 50% of vascular diameter is known as hemodynamically significant and can result in hypertension and deterioration of renal function, thus can require an invasive treatment. On the other hand, RAS < 50% of the diameter is thought to be safe. The study aimed to investigate whether renal artery narrowing < 50% of the diameter could influence renal perfusion and function.
Methods
Twenty-seven kidneys evaluated in an enhanced by contrast multidetector computed tomography (CE-MDCT; GE Discovery 750 HD) in 17 patients (6F, 11M; age 62.5 ±19.7 y) with hypertension and RAS 0-49% of the diameter were included to the study. Renal Parenchymal Perfusion (RPP), and renal function (eGFR) were evaluated.
Results
Mean eGFR was 52.4 ±26.1 mL/min/1.73m2, and RPP 222.7 ±78.7 mL/s/100g. In twelve stenotic kidneys mean RAS was 30.0 ±8.8% of the diameter. Fifteen renal arteries were normal. The severity of RAS correlated significantly (p<0.05) with RPP (r= -0.39) and eGFR (r= - 0,41). In non-stenotic kidneys RPP and eGFR were significantly higher than in those having RAS (256.4 ±82.5 vs 189.5 ±49.9 mL/s/100g; p=0.010 and 62 ±27 vs 43 ±21 mL/min/1.73 m2; p=0.045, respectively).
Conclusion
Even mild renal artery stenosis can contribute to the decrease in renal perfusion and renal function.
Due to the negative correlation of mild RAS with renal perfusion, the definition of significant RAS should be revised.
Funding
- Government Support - Non-U.S.