Abstract: SA-PO988
Immune Response to Influenza Vaccination in Dialysis Patients: Analysis of Four Consecutive Seasons
Session Information
- Hemodialysis and Frequent Dialysis - V
November 09, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 701 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Eiselt, Jaromir, Internal Dept. 1, Charles University, Plzen, Czechia
- Rajdl, Daniel, Dept. of Biochemistry, Plzen, Czechia
Background
Hemodialysis (HD) is associated with the state of immune dysfunction. In our previous study we identified low antibody response to influenza vaccine as an independent predictor of mortality in HD population. In the present study we tried to determine the factors influencing the immune response to influenza vaccination.
Methods
We analyzed data of a total of 46 HD patients who were vaccinated against influenza in four consecutive seasons from 2015/16 to 2018/19 and completed the 4-year follow-up. Their pre- and post-vaccine hemagglutination-inhibition antibody titres (HIA), iron status, C-reactive protein (CRP), albumin, parathyroid hormone and 25-OH vitamin D were measured each year at the time of vaccination. Post-vaccination seroprotection rates in consecutive seasons were compared using Cochran's Q test with multiple comparisons. To identify variables associated with the immune response to vaccine, analyses were performed using Spearman’s correlation among post-vaccine rise in HIA, demographic data and the above mentioned biomarkers.
Results
Seroprotection rates changed during the 4-year follow-up, but >70% of seroprotection against all vaccine strains was achieved in all 4 years except H1N1 strain in a 2018/19 season. Results are summarized in table 1. We did not prove significant correlations among intensity of immune response to influenza vaccine and iron status, CRP, albumin, iPTH and 25-OH vitamin D.
Conclusion
The immune response to influenza vaccine varies from year to year in the HD population, but the percentage of seroprotection, with rare exceptions, is very high. We did not find a significant association between the potential factors of immunodeficiency (markers of inflammation / malnutrition, bone metabolism or iron status) and the level of seroprotection in HD patients.
| Vaccine strain / season | 2015/16 | 2016/17 | 2017/18 | 2018/19 |
| A H1N1 SPpost (%) | 94 | 94 | 80 | 58 a |
| A H3N2 SPpost (%) | 80 | 94 | 82 | 71 b |
| B strain 1 SPpost (%) | 89 | 76 | 83 | 98 b |
| B strain 2 SPpost (%) | N/A | N/A | 78 | 98 |
Statistical analysis using Cochran's Q test with multiple comparisons; a = p<0.01 (2018/19 vesus all other years), b = p<0.05 (2018/19 versus 2016/17); N/A = not applicable
Funding
- Government Support - Non-U.S.