ASN's Mission

ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on Twitter

Kidney Week

Abstract: TH-PO1182

Prelisting Cancer Diagnosis and Outcomes in Candidates Waitlisted for Kidney Transplant

Session Information

Category: Transplantation

  • 1902 Transplantation: Clinical

Authors

  • Hart, Allyson, Hennepin County Medical Center, Minneapolis, Minnesota, United States
  • Zaun, David A., CDRG, Minneapolis, Minnesota, United States
  • Kasiske, Bertram L., Hennepin County Medical Center, Minneapolis, Minnesota, United States
  • Israni, Ajay K., Hennepin County Medical Center, Minneapolis, Minnesota, United States
  • Engels, Eric A., National Cancer Institute, Bethesda, Maryland, United States
Background

As outcomes for kidney transplant candidates with a previous history of cancer are not well described, transplant centers have difficulty determining whether and when to list such patients.

Methods

We used data from the Transplant Cancer Match Study, which links data on all solid organ transplant candidates and recipients in the US with data from 18 state and regional cancer registries, to describe outcomes for kidney transplant candidates with a pre-listing cancer diagnosis.

Results

Of 7017 kidney transplant candidates with a pre-listing history of cancer starting in 1983 (Table 1), 2600 (37.1%) were female and 4417 (62.9%) were male. Median age at listing was 59.0 years. Kidney (n=1238, 17.6%), prostate (n=1102, 15.7%), breast (n=703, 10.0%), liver (n=565, 8.1%), and colorectal (n=611, 8.7%) cancers were the most common; 5140 (73.2%) cancers were in situ or localized, 1316 (18.7%) were regional or distant stages. Median time from cancer diagnosis to listing was 4.7 years. In total, 5901 patients (84.1%) subsequently underwent transplant; 689 (9.8%) were removed from the list due to death, medical unsuitability, or deteriorating medical condition. Median time to transplant from listing was 1.2 years, with 1-year patient and graft survival 93.6% and 89.0%, respectively.

Conclusion

Many waitlisted kidney transplant candidates have a previous history of cancer, and many underwent transplant. Their data can be used to estimate likely outcomes for similar patients presenting for transplant evaluation, compared with waitlisted patients with no history of cancer.

Table 1. Demographics and waitlist outcome of 7017 patients waitlisted for kidney transplant with previous history of cancer

Funding

  • Other NIH Support