Abstract: SA-PO891
Disability and Its Association with Chronic Diseases, Especially Early CKD
Session Information
- CKD: Pharmacoepidemiology
November 09, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Lee, Dong-Young, VHS Medical Center, Seoul, Korea (the Republic of)
- Kim, Hyeonjeong, VHS Medical Center, Seoul, Korea (the Republic of)
Background
In older people muscle weakness, defects in the organs of the body are common, and in severe cases help is needed for daily life. In addition, vision, hearing are reduced, walking disorders occur, and in this condition, they are called disabled. People with disabilities need continued support from family and community people, and people with disabilities have a higher mortality rate. Disabilities are known to occur and worsen when accompanied by chronic diseases such as stroke, ischemic heart disease, arthritis, diabetes and hypertension. Plantinga et al reported that disability is also associated with chronic kidney disease (CKD) and it can be induced from early CKD. We evaluated the association between disability and various chronic diseases, especially CKD, in older Koreans.
Methods
The subjects of this study were 3rd KNHANES participants who were over 65 years old. 3rd KNHANES did not conduct a microalbuminuria test, so the definition of CKD was defined as estimated glomerular function rate<60 ml/min/1.73 m2 regardless of urine test, and the CKD stage followed the KDIGO. Disabilities included abnormal activity of daily living (ADL), instrumental ADL and vision, hearing, walking impairment.
Results
The prevalence of abnormal ADL in CKD stage 3a, stroke, arthritis, DM and hypertension were 52.2%, 42.6%, 20.1%, 25.3% and 18.7%, respectively (Table 1). The prevalence of CKD stage 3a for vision, hearing and walking impairment was significantly higher and as high as that of other chronic diseases. In multivariate logistic regression analysis, abnormal ADL is significantly associated with CKD 3a (Odds ratio, 1.78 [95% confidence interval, 1.03-3.09]).
Conclusion
CKD was associated with the disorder from the early state, and was as frequent as the previously known chronic diseases.
Prevalence of disabilities between CKD and other comorbidities
| Abnormal ADL (%) | Abnormal IADL (%) | Visual impairment (%) | Hearing impairment (%) | Walking impairment (%) | |
| DM | 25.3† | 43.2 | 60.4† | 32.9 | 51.7 |
| Hypertension | 18.7† | 39.2 | 52.6 | 29.1 | 49.8† |
| Arthritis | 20.1† | 46.8 | 58.2† | 39.8† | 63.4† |
| Cancer | 8.9 | 37.8 | 46.7 | 31.1 | 60.0 |
| Stroke | 42.6† | 62.3† | 57.4 | 37.7 | 78.7† |
| IHD | 17.9 | 44.6 | 64.3 | 33.9 | 75.0† |
| CKD 3a | 52.2† | 47.3† | 59.8† | 34.3† | 52.0† |
† p<0.005