ASN's Mission

ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on Twitter

Kidney Week

Abstract: SA-PO276

Prevalence of Kidney Stones in Patients with Enteric Disorders

Session Information

Category: Bone and Mineral Metabolism

  • 402 Bone and Mineral Metabolism: Clinical

Authors

  • Tasian, Gregory Edward, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
  • Wade, Brandon Beach, Health Advances, Weston, Massachusetts, United States
  • Gaebler, Julia A., Health Advances, Weston, Massachusetts, United States
  • Kausz, Annamaria T., Allena Pharmaceuticals, Newton, Massachusetts, United States
  • Medicis, Joe, Allena Pharmaceuticals, Newton, Massachusetts, United States
  • Wyatt, Christina M., Duke University School of Medicine, Durham, North Carolina, United States
Background

Hyperoxaluria (HOx) is a serious metabolic disorder and a risk factor for kidney stone disease (KSD) and chronic kidney disease (CKD). Enteric HOx (EH) develops as a complication of increased intestinal oxalate absorption due to an underlying GI disorder (e.g., bariatric surgery, inflammatory bowel disease (IBD). The prevalence of EH is not well described, due in part to infrequent testing for risk factors of KSD and the lack of a specific diagnostic code for EH. We sought to estimate the prevalence of EH and the distribution of underlying enteric causes.

Methods

We developed a state-transition Markov model to estimate the current US prevalence of malabsorptive enteric disorders and the total number of stone-forming patients using data from the published literature and from a four-year claims analysis (6/2012-6/2016) from the IBM Truven Health Analytics system. Patients with a malabsorptive enteric disorders (Roux-en-Y Gastric Bypass, Short Bowel Syndrome, Inflammatory Bowel Disease (IBD), Chronic Pancreatitis, and Celiac Disease) who had KSD or KSD and CKD were considered to have EH.

Results

The 2019 prevalence was determined to be 249,048 and the most frequent malabsorptive enteric conditions were Roux-en-Y gastric bypass at 62% and inflammatory bowel disease at 20%.

Conclusion

EH is associated with serious consequences, yet its prevalence is poorly understood. Based on this analysis of data across various sources, there are approximately 250,000 EH patients with kidney stone disease in the US, including those who develop CKD. Additional epidemiological research and a specific diagnostic code could further improve efforts to understand and improve the recognition of EH.

Prevalence of enteric hyperoxaluria with kidney stones
Roux-en-Y gastric bypass154,722 (62%)
IBD48,614 (20%)
Celiac disease29,118 (12%)
Chronic pancreatitis13,647 (5%)
Short bowel syndrome2,947 (1%)
Total 249,048

Funding

  • Commercial Support