Abstract: SA-PO276
Prevalence of Kidney Stones in Patients with Enteric Disorders
Session Information
- Bone and Mineral Metabolism: Calcium, Magnesium, Kidney Stones
November 09, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Bone and Mineral Metabolism
- 402 Bone and Mineral Metabolism: Clinical
Authors
- Tasian, Gregory Edward, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
- Wade, Brandon Beach, Health Advances, Weston, Massachusetts, United States
- Gaebler, Julia A., Health Advances, Weston, Massachusetts, United States
- Kausz, Annamaria T., Allena Pharmaceuticals, Newton, Massachusetts, United States
- Medicis, Joe, Allena Pharmaceuticals, Newton, Massachusetts, United States
- Wyatt, Christina M., Duke University School of Medicine, Durham, North Carolina, United States
Background
Hyperoxaluria (HOx) is a serious metabolic disorder and a risk factor for kidney stone disease (KSD) and chronic kidney disease (CKD). Enteric HOx (EH) develops as a complication of increased intestinal oxalate absorption due to an underlying GI disorder (e.g., bariatric surgery, inflammatory bowel disease (IBD). The prevalence of EH is not well described, due in part to infrequent testing for risk factors of KSD and the lack of a specific diagnostic code for EH. We sought to estimate the prevalence of EH and the distribution of underlying enteric causes.
Methods
We developed a state-transition Markov model to estimate the current US prevalence of malabsorptive enteric disorders and the total number of stone-forming patients using data from the published literature and from a four-year claims analysis (6/2012-6/2016) from the IBM Truven Health Analytics system. Patients with a malabsorptive enteric disorders (Roux-en-Y Gastric Bypass, Short Bowel Syndrome, Inflammatory Bowel Disease (IBD), Chronic Pancreatitis, and Celiac Disease) who had KSD or KSD and CKD were considered to have EH.
Results
The 2019 prevalence was determined to be 249,048 and the most frequent malabsorptive enteric conditions were Roux-en-Y gastric bypass at 62% and inflammatory bowel disease at 20%.
Conclusion
EH is associated with serious consequences, yet its prevalence is poorly understood. Based on this analysis of data across various sources, there are approximately 250,000 EH patients with kidney stone disease in the US, including those who develop CKD. Additional epidemiological research and a specific diagnostic code could further improve efforts to understand and improve the recognition of EH.
| Prevalence of enteric hyperoxaluria with kidney stones | |
| Roux-en-Y gastric bypass | 154,722 (62%) |
| IBD | 48,614 (20%) |
| Celiac disease | 29,118 (12%) |
| Chronic pancreatitis | 13,647 (5%) |
| Short bowel syndrome | 2,947 (1%) |
| Total | 249,048 |
Funding
- Commercial Support – Allena Pharmaceuticals