ASN's Mission

ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on Twitter

Kidney Week

Abstract: TH-PO694

Plasma Xanthine Oxidoreductase Activity Is Associated with CKD in a General Japanese Population: The Iwate Tohoku Medical Megabank Project

Session Information

Category: Hypertension and CVD

  • 1401 Hypertension and CVD: Epidemiology, Risk Factors, and Prevention

Authors

  • Kotozaki, Yuka, Iwate Medical University, Yahaba, Japan
  • Tanno, Kozo, Iwate Medical University, Yahaba, Japan
  • Asahi, Koichi, Iwate Medical University, Yahaba, Japan
  • Ohmomo, Hideki, Iwate Medical University, Yahaba, Japan
  • Otomo, Ryo, Iwate Medical University, Yahaba, Japan
  • Tanaka, Fumitaka, Iwate Medical University, Yahaba, Japan
  • Shimizu, Atsushi, Iwate Medical University, Yahaba, Japan
  • Sakata, Kiyomi, Iwate Medical University, Yahaba, Japan
  • Hitomi, Jiro, Iwate Medical University, Yahaba, Japan
  • Sasaki, Makoto, Iwate Medical University, Yahaba, Japan
  • Satoh, Mamoru, Iwate Medical University, Yahaba, Japan
Background

Xanthine oxidoreductase (XOR, pmol/h/mL plasma) catalyzes the oxidation of hypoxanthine to xanthine and of xanthine to uric acid. An increase in XOR activity could cause intravascular damage through the oxidative stress. XOR activity could contribute to the pathogenesis of cardiovascular disease (CVD). Chronic kidney disease (CKD) and CVD are closely related. However, the association with XOR activity and CKD in a general Japanese population are not known. The purpose of this study is to investigate the association between XOR activity and CKD in a general Japanese population.

Methods

The Iwate Tohoku Medical Megabank Organization pooled individual participant data from a general population-based cohort study in Iwate prefecture (n = 1,675, male / female = 529 / 1,146, age = 66.2 ± 10.1 years). We classified as CKD stage (stage I ~ stage IV) using the estimate glomerular filtration rate of creatinine (eGFR, mL/min/1.73m2; eGFR < 60) and the urinary albumin to creatinine ratio (uacr, mg/gCr; uacr ≥ 30). Suita Score used to estimate the risk of the CVD. XOR activity was expressed as the log-transformed values (log10) for skewed variables.

Results

In males, XOR activity was significantly lower in stage IV of CKD compared to stage II (F = 4.66, p = 0.003; stage II vs. IV, 1.74 ± 0.38 vs. 1.27 ± 0.52, p = 0.009), and was related to CKD (OR = 1.87, 95% confidence interval (CI) = 1.16 – 3.01, p = 0.011). XOR activity was no significant difference among CKD stages in females (F = 1.73, p = 0.159), and was no related to CKD (OR = 1.19, p = 0.375). XOR activity was related to the high risk for CVD (Suita Score ≥ 41, males: OR = 4.24, 95% CI = 1.75 – 10.35, p = 0.001; females: OR = 2.88, 95% CI = 2.01 – 4.13, p < 0.001). The area under the curve (AUC) for XOR activity combined with Suita score was 0.61 (95% CI = 0.50 – 0.72, p = 0.051).

Conclusion

In conclusion, XOR activity is associated with CKD and the high risk for CVD in a general Japanese population. An increase in XOR activity may be related to decreased renal function and the CVD risk.

Funding

  • Government Support - Non-U.S.