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Abstract: TH-PO055

Urinary Activin A: A Novel Biomarker for Monitoring the Severity of AKI

Session Information

Category: Acute Kidney Injury

  • 101 AKI: Epidemiology, Risk Factors, and Prevention

Authors

  • Nagayama, Izumi, Jichi Medical University, Shimotsuke, Tochigi, Japan
  • Maeshima, Akito, Jichi Medical University, Shimotsuke, Tochigi, Japan
  • Nagata, Daisuke, Jichi Medical University, Shimotsuke, Tochigi, Japan
Background

Acute kidney injury (AKI) is a common but complex condition that is associated with increased morbidity and mortality. There is a need for biomarkers to predict AKI development and severity in critically ill patients. We previously reported that activin A, a member of the TGF-beta superfamily, which was absent in normal kidney, was increased in the ischemic rat kidney and negatively regulates the repair process of the kidney after injury (Maeshima et al. J Am Soc Nephrol 2001). However, the dynamics and significance of urinary activin A have not been clarified in humans. To address this issue, we examined whether urinary activin A can be detectable in human AKI and may serve as a biomarker to predict AKI development and severity.

Methods

Thirty three patients with AKI (renal AKI 22, pre-renal AKI 11) were enrolled in this study approved by the institutional review board of the Jichi Medical University Hospital (Approved number A18-081, A18-089). Written informed consent was obtained from all participants. The Kidney Disease Improving Global Outcomes (KDIGO) classification was used to diagnose and classify patients developing AKI. Serum and urinary activin A was measured by ELISA. Correlations of urinary activin A with other clinical parameters were analyzed.

Results

Urinary activin A, which was almost undetectable in pre-renal AKI, was significantly increased in renal AKI (6.0 ± 3.17 vs. 204.8 ± 96.6 pg/mL, p<0.05). Urinary activin A level in patients with AKI stage III was significantly higher than that in patients with AKI stage I + II (199.4 ± 102.8 vs. 32.8 ± 16.3 pg/mL, p<0.05). There was a significant correlation of urinary activin A level with urinary NGAL, NAG, and alpha-1 microglobulin, but not with L-FABP, urinary protein, serum creatinine, and serum activin A. In one patient with drug-induced AKI who recovered renal function to normal, urinary activin A rapidly decreased before the normalization of serum creatinine, NGAL and L-FABP. In other patient with AKI due to contrast nephropathy, who did not recover renal function, urinary activin A remained at high level at 1 month after the initiation of hemodialysis therapy.

Conclusion

Urinary activin A can be detected in human with AKI and might be a useful and non-invasive biomarker for monitoring the severity of AKI.

Funding

  • Government Support - Non-U.S.