Kidney Week

Abstract: SA-PO910

Resistance Exercise Training in CKD: A Randomized Pilot Trial

Session Information

• CKD: Clinical, Outcomes, Trials - III
  November 09, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2102 CKD (Non-Dialysis): Clinical, Outcomes, and Trials

Authors

• Ando, Akika, University of Illinois at Chicago, Chicago, Illinois, United States

Akika Ando,

• Grigoriadis, Georgios, University of Illinois at Chicago, Chicago, Illinois, United States

Georgios Grigoriadis,

• Caldwell, Jillian, University of Illinois at Chicago, Chicago, Illinois, United States

Jillian Caldwell,

• Mcmillan, Neil, University of Illinois at Chicago, Chicago, Illinois, United States

Neil Mcmillan,

• Baynard, Tracy, University of Illinois at Chicago, Chicago, Illinois, United States

Tracy Baynard,

• Carmona, Eunice, University of Illinois at Chicago, Chicago, Illinois, United States

Eunice Carmona,

• Ansari, Sajid Q., University of Illinois at Chicago, Chicago, Illinois, United States

Sajid Q. Ansari,

• Dabbas, Walaa Said, University of Illinois at Chicago, Chicago, Illinois, United States

Walaa Said Dabbas,

• Chen, Jinsong, University of Illinois at Chicago, Chicago, Illinois, United States

Jinsong Chen,

• Fernhall, Bo, University of Illinois at Chicago, Chicago, Illinois, United States

Bo Fernhall,

• Ricardo, Ana C., University of Illinois at Chicago, Chicago, Illinois, United States

Ana C. Ricardo,

Group or Team Name

• University of Illinois at Chicago, Nephrology Department

Background

Resistance exercise training has been shown to improve vascular function and cardiovascular risk factors in healthy individuals, but studies in patients with chronic kidney disease (CKD) are lacking.

Methods

We randomly assigned adults with mild-to-moderate CKD to a 12-week resistance exercise training intervention (45-minutes sessions, twice per week) or to control (educational material regarding the benefits of physical activity). The primary outcomes were aortic pulse-wave velocity (PWV), carotid artery stiffness and systolic blood pressure (BP), measured at baseline, 6 weeks and 12 weeks. Intention-to-treat analyses with repeated measures ANOVA were used.

Results

Of the 32 individuals included in the analyses (15 randomized to the intervention group and 17 to the control group), mean (SD) age was 57 (1.8) years, 47% were male, 94% African American, and 27% had diabetes; mean (SD) eGFR was 42 (14) ml/min/1.73m². Of those randomized to the resistance exercise intervention, 67% completed at least half of the training sessions. No adverse effects were observed with the intervention. There was a decrease in PWV, carotid stiffness and systolic BP among participants randomized to resistance exercise training, but these changes were not statistically significant when compared with controls (Table).

Conclusion

Resistance exercise training is feasible and safe among patients with CKD, and has the potential of improving vascular function in this population.

Funding

• NIDDK Support