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Abstract: SA-PO807

The High Dietary Polyunsaturated Fatty Acid Level Is Associated with Lower Prevalence of CKD: A Population-Based Cohort Study

Session Information

Category: Health Maintenance, Nutrition, and Metabolism

  • 1300 Health Maintenance, Nutrition, and Metabolism

Authors

  • Park, Jimin, Yonsei University, Seoul, Korea (the Republic of)
  • Kim, Seonghun, Yonsei University, Seoul, Korea (the Republic of)
  • Nam, Boyoung, Yonsei University, Seoul, Korea (the Republic of)
  • Kang, Shinchan, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
  • Yoo, Tae-Hyun, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
Background

There have been steady interests in the effects of polyunsaturated fatty acid (PUFA) on health and several studies have proved PUFA is associated with lower risk of hypertension and diabetes. However, the effect of dietary PUFA on renal function in general population has been relatively unexplored, yet. Therefore, we aimed to evaluate the relationship between dietary PUFA intake and renal function in a nationwide nutritional survey.

Methods

Data were retrieved from the Korea National Health And Nutrition Examination Survey (KNHANES). Among 39,225 subjects collected from 2013 to 2017, 22,079 subjects were included in final analysis, after exclusion of those who were under 18 or whose baseline data were missing. FPF (fraction of PUFA among dietary fat intake) was defined as percentage of daily PUFA intake (g) relative to daily total fat intake (g). The subjects were categorized into quartiles according to the FPF. Primary outcome was defined as a prevalent chronic kidney disease (CKD) with estimated glomerular filtration rate (eGFR) by Korean version of CKD-EPI < 60 mL/min/1.73 m2 and composite outcome was eGFR < 60 mL/min/1.73 m2 or the presence of proteinuria, defined as ≥ 1+ by dipstick urine test.

Results

The mean age and eGFR of the subject were 51.1 ± 16.4 years and 94.6 ± 18.8 mL/min/1.73 m2, respectively. The mean FPF was 26.4 ± 10.0 %. Interestingly, the subjects in higher FPF group tended to be older and have slightly lower eGFR compared to those in lower FPF group. Moreover, they had lower daily fat intake and higher prevalence of HTN, DM and dyslipidemia. Total 899 subjects were found to have prevalent CKD and 1,106 subjects had composite outcomes. Multivariable logistic regression analyses revealed that the risk of CKD was lower in the group with the highest FPF compared to the lowest FPF group after adjustment for confounding factors [odds ratio (OR) 0.71, 95% confidence interval (CI) 0.58-0.88, P = 0.002]. This finding was consistent in terms of composite outcome (OR 0.75, 95% CI 0.62-0.90, P = 0.002).

Conclusion

The risk for CKD was lower in the subjects with the high dietary PUFA. Fraction of PUFA among dietary fat may affects renal function in healthy population.