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Abstract: TH-PO220

Correlation Between Arterial Stiffness and Body Fat in Hemodialysis Patients

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis

Authors

  • Wang, Lulu, Nanjing Medical University, Nanjing, China
  • Zhuang, Bing, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
  • Bian, Xueqin, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
  • Luo, Yuan, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
  • Ye, Hong, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
  • Yang, Junwei, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
Background

Arterial stiffness is common in chronic kidney disease. It has been known that the traditional risk factors such as ageing, hypertension and diabetes are linked to aortic elasticity. Few studies have focused on peripheral arterial elasticity. Some clinical trials have found a nonlinear relationship between body fat percentage and atherosclerosis in general population. Here, we explore the correlation between body fat and arterial elasticity in hemodialysis patients by measuring a variety of body fat indexes.

Methods

A total of 166 patients on maintenance were included in the study. All subjects underwent arterial elasticity examination and body fat assessment. Basic information of body fat was collected including height,weight,waist circumference, hip circumference, triceps skin fold thickness, and subscapular skin fold thickness. We used human body composition analyzer (Inbody S10) to assess body fat mass, body fat percentage and visceral fat area.

Results

The mean age were 49.9±11.2 years old. Median cfPWV and crPWV was 9.3±2.8 m/s and 9.6±1.7 m/s,respectively. After adjusted to age, sex and other confounding factors, only skin fold thickness(β=-0.041,p=0.022) was associated with cfPWV. Body fat indexes including triceps and subscapular skinfold thickness, BMI, body fat percentage, body fat mass, visceral fat area were significantly negative correlated with crPWV (all p<0.001). We performed a gender- stratified subgroup analysis and found that significant associations between triceps(β=-0.065,p=0.009), subscapular skinfold thickness(β=-0.063,p<0.001)and crPWV were observed in male patients.

Conclusion

The effect of body fat indexes on arterial elasticity was mainly concentrated in peripheral artery. The association between subcutaneous fat and peripheral arterial stiffness significant mainly in males rather than in females.

Funding

  • Government Support - Non-U.S.