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Abstract: FR-PO291

Glomerular Hyperfiltration Is Associated with Dementia: A Nationwide Population-Based Study

Session Information

Category: CKD (Non-Dialysis)

  • 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

  • Kang, Min woo, Seoul National University Hospital, Seoul, Korea (the Republic of)
  • Lee, Soojin, Seoul National University Hospital, Seoul, Korea (the Republic of)
  • Lee, Yeonhee, Seoul National University College of Medicine, Seoul, Korea (the Republic of)
  • Kim, Yaerim, Seoul National University Hospital, Seoul, Korea (the Republic of)
  • Lee, Hajeong, Seoul National University College of Medicine, Seoul, Korea (the Republic of)
  • Lee, Jung Pyo, Seoul National University Boramae Medical Center, Seoul, Korea (the Republic of)
  • Joo, Kwon Wook, Seoul National University Hospital, Seoul, Korea (the Republic of)
  • Lim, Chun Soo, Seoul National University Boramae Medical Center, Seoul, Korea (the Republic of)
  • Kim, Yon Su, Seoul National University College of Medicine, Seoul, Korea (the Republic of)
  • Kim, Dong Ki, Seoul National University Hospital, Seoul, Korea (the Republic of)
Background

Because prevention of dementia is critical before it occurs, identifying the risk factor of dementia is important. The object of this study is to identify the risk of dementia in people with glomerular hyperfiltration.

Methods

Using Korean National Health Information Database (NHID), we retrospectively reviewed total of 2,244,582 people, excluding ESRD patients and people with dementia before taking national health screening. Study population was divided into gender and age of five-years interval group. All eGFR≥95 percentile subjects in each group which was divided into sex and age of five-years were defined as hyperfiltration group. All 50 percentile≤eGFR<65 percentile subjects in each group which was divided into sex and age of five-years were defined as reference group. The hazard ratios (HR) for all type dementia, vascular dementia and Alzheimer’s dementia were calculated within the study groups after adjustment for multiple variables.

Results

The corresponding eGFR values of hyperfiltration (95 percentile of eGFR) group were ≥114 mL/min/1.73m2 in 45-49 years old male, ≥83 mL/min/1.73m2 in ≥90 years old male and ≥117 mL/min/1.73m2 in 45-49 years old female, ≥85 mL/min/1.73m2 in ≥90 years old female. (Figure 1.) The hyperfiltration group (eGFR≥95percentile) showed a higher risk of all type dementia compared with the reference group (50percentile≤eGFR<65percentile), with the following HRs: 1.09 (95% CI: 1.032–1.152). The hyperfiltration group had higher risk of vascular dementia with the following HR: 1.33 (95% CI: 1.137–1.549). The relationship between hyperfiltration and Alzheimer's dementia was not statistically significant, with the following HRs: 1.040 (95% CI: 0.977–1.108). (Figure 2.)

Conclusion

Glomerular hyperfiltration is associated with increased risk of dementia, especially vascular dementia.