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Kidney Week

Abstract: TH-PO056

Description of [TIMP-2] [IGFBP7] Significative Values at 72 Hours After Cardiac Surgery for Predicting AKI

Session Information

Category: Acute Kidney Injury

  • 101 AKI: Epidemiology, Risk Factors, and Prevention


  • Rizo Topete, Lilia Maria, Hospital Universitario, UANL, Monterrey, Nuevo Leon, Mexico
  • Ronco, Claudio, University of Padova, IRRIV, San Bortolo Hospital, Vicenza, Italy
  • Lorenzin, Anna, IRRIV, Vicenza, Italy
  • Ferrari, Fiorenza, I.R.C.C.S. policlinico San matteo, Pavia, Italy
  • Romero, Gregorio Aramid, Hospital Universitario Basurto, Bilbao, Spain

AKI is common in critically ill patients and has been identified as an independent mortality predictor. Multiple biomarkers has been discovered in order to improve tools for AKI diagnosis. The aim of this study was AKI within the first 72 hours after cardiac surgery. Secondary endpoints were severity of AKI within 72 h, need for RRT, length of stay in the UCI and death during the ICU stay in relation with [TIMP-2] [IGFBP7]


Observational, prospective study. Patients 18Y, with or without AKI who underwent cardiac surgery ,June to December 2016. A statistical analysis was performed. Urine samples for measurement of [TIMP-2] [IGFBP7] were collected 4 h after ICU admission. High risk for AKI was defined as urinary [TIMP-2] [IGFBP7] 0.3 (ng/mL)2/1000.


383 patients , 77 (20.1%) developed AKI within 72 h. At baseline (pre-ICU) age was AKI group [67 (58 – 74) vs74 (70 – 78); p=<0.0001]. The diuretic use [122 (41.5%) vs 42 (56.8%); p= 0.026]. Vancomycin during the surgery was significantly higher in the AKI group [122 (41.4%) vs 42 (56.8%); p=0.026]. The prevalence at 72 h of ICU admission was 77 (20.1%) patients and the severity AKI 1 60 (15.7%) patients, AKI 2 11 (2.9%) patients and AKI 3 6 (1.6%) patients. In those patients with AKI within 72 hours and [TIMP-2][IGFBP7] >0.3 (ng/mL)2/1000 had higher significantly FB in the first 6h [2.05 ± 933.84 vs 252.97 ± 761.26; p=0.016]. Cardiac arrest [1 (0.3%) vs (6 (8.2%); p=<0.0001], reintervention during the ICU stay [6 (2%) versus 6 (8.2%); p=0.017], LOS in ICU [7 (6 – 10) vs 9 (7 – 15.5); p=<0.0001] and death [52 (17%) vs 23 (29.9%); p=0.015] were significantly higher in the AKI group.


In high risk patients, [TIMP-2][IGFBP7] should be considered together with other clinical parameters to predict AKI and adverse outcomes (Cardiac arrest, Length of stay and death) .