Abstract: SA-PO499
Immunosenescence in Type 2 Diabetic Patients with Chronic Renal Disease
Session Information
- Diabetic Kidney Disease: Basic - III
November 09, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Diabetic Kidney Disease
- 601 Diabetic Kidney Disease: Basic
Authors
- Shu, Kai-Hsiang, National Taiwan University, Taipei, Taiwan
- Lay, Fang-Yun, Far Eastern Memorial Hospital, New Taipei City, Taiwan
- Pan, Szu-Yu, Far Eastern Memorial Hospital, New Taipei City, Taiwan
- Chiu, Yen-Ling, Far Eastern Memorial Hospital, New Taipei City, Taiwan
Background
Immunosenescence is an important challenge for an aging population. It is known that patients with end-stage renal disease suffer from immunosenescence and premature T cell aging but whether such changes occur in diabetic patients with less severe chronic renal disease is unclear.
Methods
832 patients with type 2 diabetes with different levels of renal function were recruited in this study. Immunosenescence was analyzed by staining peripheral blood with two immunophenotyping panels and analyzed by multicolor flow cytometry.
Results
Out of all the 832 participants, there were 171 patients with stage 3 CKD and 46 patients with 4/5 CKD. Compared to patients with eGFR>60 ml/min, patients with more severe CKD showed progressive decreased total CD3+ T cell and CD4+ and CD8+ T cell, but not monocyte numbers. In addition, immunosenescence, as defined by various phenotypic markers, showed significant upregulation in both stage 3 and stage 4/5 patients. However, immunosenescence was not associated with proteinuria level nor worse glucose control. In age and sex adjusted regression models, stage 3 CKD patients already exhibited significant elevated percentages of CD28-, CD127- and CD57+ cells among CD8+ T cells when compared to patients with eGFR>60 ml/min. In addition, stage 3 CKD patients exhibited depressed HLA-DR and CX3CR1 expression in specific monocyte subpopulations.
Conclusion
Level of immunosenescence is not significantly associated with proteinuria nor glucose control in type 2 diabetes patients. Both T cell and monocyte compartment exhibit characteristics of immunosenescence during renal function decline, starting from stage 3 CKD.