Kidney Week

Abstract: TH-PO1126

Influence of Donor Characteristics and Delayed Graft Function (DGF) on Renal Function 12 Months After Kidney Transplantation

Session Information

• Transplantation: Clinical - Predictors of Outcomes - Biomarkers and Beyond
  November 07, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Transplantation

• 1902 Transplantation: Clinical

Authors

• Roberto, Fernanda B., Hospital do Rim - UNIFESP, Sao Paulo, Brazil

Fernanda B. Roberto,

• Foresto, Renato Demarchi, Hospital do Rim - UNIFESP, Sao Paulo, Brazil

Renato Demarchi Foresto,

• Hazin, Maria Amelia, Hospital do Rim - UNIFESP, Sao Paulo, Brazil

Maria Amelia Hazin,

• Vilanova, Maria Eduarda, Hospital do Rim - UNIFESP, Sao Paulo, Brazil

Maria Eduarda Vilanova,

• Gonzalez, Diego Ennes, Hospital do Rim - UNIFESP, Sao Paulo, Brazil

Diego Ennes Gonzalez,

• Takara, Luiz Eduardo massao, Hospital do Rim - UNIFESP, Sao Paulo, Brazil

Luiz Eduardo massao Takara,

• Cristelli, Marina Pontello, Hospital do Rim - UNIFESP, Sao Paulo, Brazil

Marina Pontello Cristelli,

• Viana, Laila Almeida, Hospital do Rim - UNIFESP, Sao Paulo, Brazil

Laila Almeida Viana,

• Felipe, Claudia Rosso, Hospital do Rim - UNIFESP, Sao Paulo, Brazil

Claudia Rosso Felipe,

• Silva, Helio Tedesco, Hospital do Rim - UNIFESP, Sao Paulo, Brazil

Helio Tedesco Silva,

• Medina-Pestana, J., Hospital do Rim - UNIFESP, Sao Paulo, Brazil

J. Medina-Pestana,

Group or Team Name

• Hospital do Rim

Background

The KDPI (Kidney Donor Profile Index) index is a score based on donor characteristics used to predict long-term graft survival. Delayed graft function (DGF), a variable not included in the KDPI score, is associated with reduced graft survival. We hypothesized that increasing KDPI scores and DGF concur to reduce renal function 1 and 12 months after kidney transplantation.

Methods

This single center retrospective study included all consecutive deceased donor kidney transplant recipients (n=1221) between January 2014 to December 2015. Analysis was carried out according to deciles of KPDI. Renal function was evaluated by estimated glomerular filtration rate (eGFR, calculated by the MDRD4 formula).

Results

The mean cold ischemia time was 25±7 hours and it was similar across the deciles of KPDI. The incidence of DGF increased from 39% to 75% (p = 0.001) from 0-10% to 91-100% KDPI deciles. The 1 month eGFR showed a negative association with KDPI deciles, 59.5 vs. 39.0 ml/min/1.73m² (p<0.001) for 0-10% and 91-100% KDPI deciles. This trend persisted in the 12 month analysis (64.6 vs. 46.0 ml/min/1.73m²; p<0.001), respectively. DGF was associated with lower 1 month eGFR across all the KDPI deciles (KDPI [0-10%] 67.9 vs. 46.2 ml/min/1.73m², p=0.029; KDPI [91-100%] 47.7 vs. 36.2 ml/min/1.73m², p<0.001), but this trend decreased at 12 months (KDPI [0-10%] 65.5 vs. 63.1 ml/min/1.73m², p=0.84; KDPI [91-100%] 47.5 vs. 45.4 ml/min/1.73m², p=0.425).

Conclusion

Renal function 1 and 12 months after kidney transplantation is determined primarily by donor characteristics (KDPI) and the development of DGF.