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Kidney Week

Abstract: FR-PO1150

Health-Related Quality of Life Among Kidney Transplant Patients Using the PROMIS Global Health Scale

Session Information

Category: Transplantation

  • 1902 Transplantation: Clinical

Authors

  • Peipert, John D., Northwestern University, Chicago, Illinois, United States
  • Koraishy, Farrukh M., Saint Louis University, Saint Louis, Missouri, United States
  • Waterman, Amy D., UCLA Transplant Research and Education Center, Los Angeles, California, United States
  • Schnitzler, Mark, Saint Louis Univ, Shiloh, Illinois, United States
  • Lentine, Krista L., Saint Louis University, Saint Louis, Missouri, United States
Background

Survival after kidney transplant (KT) is increasing, turning attention to health-related quality of life (HRQOL). Brief but valid measures are needed to screen HRQOL among KT patients. We examined the 10-item PROMIS Global Health Scale (GHS) pre- and post-transplant among KT patients. We also examined GHS scores among a cohort of liver transplant (LT) patients for comparison.

Methods

Data were from KT and LT patients at a transplant center in the United States. PROMIS GHS was assessed pre-transplant (KT, n=189; LT, n=88) and 6 months post-transplant (KT, n=43; LT, n=16). We estimated global physical health (GPH) and global mental health (GMH) summary scores from the GHS. We compared KT and LT to the US general population normative mean value of 50. We then estimated associations between PROMIS GPH and GMH scores with clinician-rated functional status sourced from the Scientific Registry for Transplant Recipients.

Results

Among KT patients, the mean GPH and GMH scores at pre-transplant were 46.3 and 50.2, respectively, which increased to 51.1 and 54.1 at 6 months post-transplant. As expected, LT patients had lower physical and mental HRQOL than KT patients. Among LT patients, mean GPH and GMH scores at pre-transplant were 42.1 and 46.3, respectively, which increased to 44.7 and 50.1 at 6 months post-transplant. Pre-transplant differences in functional status were not statistically significant for KT patients. However, in comparison to LT patients with normal function, LT recipients unable to carry-on normal activities had significantly lower mean GPH (39.9 vs. 47.4, p<0.001) and GMH (44.5 vs. 50.3, p=0.01) scores.

Conclusion

The PROMIS GHS is a brief, clinically-feasible, and patient-centered approach to tracking changes in patients’ health over time for KT and LT patients. Inclusion of patient-reported outcomes like the GHS can enhance the standard health metrics collected for transplant patients.