Abstract: TH-PO852
Peak Renal Blood Flow Rate Correlates with Renal Function in Adults with ADPKD
Session Information
- Cystic Kidney Diseases: Clinical
November 07, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Genetic Diseases of the Kidneys
- 1001 Genetic Diseases of the Kidneys: Cystic
Authors
- Schäfer, Michal, Div. Renal Diseases and Hypertension,, Aurora, Colorado, United States
- Bjornstad, Petter, University of Colorado School of Medicine, Aurora, Colorado, United States
- Bispham, Nina, University of Colorado , Aurora, Colorado, United States
- You, Zhiying, UC Denver, Aurora, Colorado, United States
- Nowak, Kristen L., University of Colorado Denver: Anschutz Medical Campus, Aurora, Colorado, United States
- Hopp, Katharina, University of Colorado Denver, AMC, Aurora, Colorado, United States
- Brosnahan, Godela M., University of Colorado Denver, Aurora, Colorado, United States
- Chonchol, Michel, University of Colorado , Aurora, Colorado, United States
- Gitomer, Berenice Y., Div. Renal Diseases and Hypertension,, Aurora, Colorado, United States
Background
Changes in renal blood flow (RBF) occur early in the course of autosomal dominant polycystic kidney disease (ADPKD) and precede the decline in glomerular filtration rate (GFR). The specific hemodynamic factors responsible for the decline in RBF and GFR in ADPKD are poorly defined. The objective of this study was to determine the relationships between flow hemodynamic parameters and GFR in adults with ADPKD.
Methods
All participants provided informed consent and studies were performed in accordance with the Helsinki guidelines. Renal flow indices were obtained by phase-contrast MRI situated in the mid-section of renal arteries. Images were acquired as previously described by the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP). GFR was measured by 125I-iothalamate clearance.
Results
Forty-five participants (18 male and 27 female) with a confirmed diagnosis of ADPKD were included in the study. The participant characteristics are shown in Table 1. Both Max Q (ml/s) (peak renal RBF)(r = 0.52, p= 0.05) and Min Q (ml/s) (minimum RBF)(r = 0.52, p = 0.04) were significantly positively correlated with measured absolute GFR ml/min. This relationship was independent of age, sex, systolic blood pressure and body mass index. However, neither total blood flow volume (ml) or maximum flow velocity (cm/s) correlated with measured GFR.
Conclusion
In this cohort of people with ADPKD with preserved kidney function both peak and minimum RBF rates significantly correlated with measured GFR. These data suggest that early hemodynamic alterations may be useful biomarkers of kidney function in early disease.
Demographic characteristics of the study population
| Parameter | Mean (N = 45) | Standard deviation |
| Sex M/F | 18/27 | |
| Age (years) | 41 | 9 |
| Body Mass Index | 27.0 | 6.3 |
| Iothalamate GFR (ml/min) | 101 | 28 |
| Estimated GFR (ml/min/1.73m^2) | 92 | 17 |
| Systolic Blood Pressure (mmHg) | 124 | 11 |
Funding
- Other U.S. Government Support