ASN's Mission

ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on Twitter

Kidney Week

Abstract: TH-PO852

Peak Renal Blood Flow Rate Correlates with Renal Function in Adults with ADPKD

Session Information

Category: Genetic Diseases of the Kidneys

  • 1001 Genetic Diseases of the Kidneys: Cystic

Authors

  • Schäfer, Michal, Div. Renal Diseases and Hypertension,, Aurora, Colorado, United States
  • Bjornstad, Petter, University of Colorado School of Medicine, Aurora, Colorado, United States
  • Bispham, Nina, University of Colorado , Aurora, Colorado, United States
  • You, Zhiying, UC Denver, Aurora, Colorado, United States
  • Nowak, Kristen L., University of Colorado Denver: Anschutz Medical Campus, Aurora, Colorado, United States
  • Hopp, Katharina, University of Colorado Denver, AMC, Aurora, Colorado, United States
  • Brosnahan, Godela M., University of Colorado Denver, Aurora, Colorado, United States
  • Chonchol, Michel, University of Colorado , Aurora, Colorado, United States
  • Gitomer, Berenice Y., Div. Renal Diseases and Hypertension,, Aurora, Colorado, United States
Background

Changes in renal blood flow (RBF) occur early in the course of autosomal dominant polycystic kidney disease (ADPKD) and precede the decline in glomerular filtration rate (GFR). The specific hemodynamic factors responsible for the decline in RBF and GFR in ADPKD are poorly defined. The objective of this study was to determine the relationships between flow hemodynamic parameters and GFR in adults with ADPKD.

Methods

All participants provided informed consent and studies were performed in accordance with the Helsinki guidelines. Renal flow indices were obtained by phase-contrast MRI situated in the mid-section of renal arteries. Images were acquired as previously described by the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP). GFR was measured by 125I-iothalamate clearance.

Results

Forty-five participants (18 male and 27 female) with a confirmed diagnosis of ADPKD were included in the study. The participant characteristics are shown in Table 1. Both Max Q (ml/s) (peak renal RBF)(r = 0.52, p= 0.05) and Min Q (ml/s) (minimum RBF)(r = 0.52, p = 0.04) were significantly positively correlated with measured absolute GFR ml/min. This relationship was independent of age, sex, systolic blood pressure and body mass index. However, neither total blood flow volume (ml) or maximum flow velocity (cm/s) correlated with measured GFR.

Conclusion

In this cohort of people with ADPKD with preserved kidney function both peak and minimum RBF rates significantly correlated with measured GFR. These data suggest that early hemodynamic alterations may be useful biomarkers of kidney function in early disease.

Demographic characteristics of the study population
ParameterMean (N = 45)Standard deviation
Sex M/F18/27 
Age (years)419
Body Mass Index27.06.3
Iothalamate GFR (ml/min)10128
Estimated GFR (ml/min/1.73m^2)9217
Systolic Blood Pressure (mmHg)12411

Funding

  • Other U.S. Government Support