Abstract: FR-PO315
CT Mapping of Spinal and Vascular Abdominal Urate Deposition with Correlation to Uric Acid Level
Session Information
- CKD: Clinical, Outcomes, Trials - II
November 08, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2102 CKD (Non-Dialysis): Clinical, Outcomes, and Trials
Authors
- Abdellatif, Waleed, University of British Columbia, Vancouver, British Columbia, Canada
- Lee, Juvel, University of British Columbia, Vancouver, British Columbia, Canada
- Jung, Sunghan, University of British Columbia, Vancouver, British Columbia, Canada
- Negida, Ahmed, Zagazig University, Zagazig, Egypt
- Gong, Bo, University of British Columbia, Vancouver, British Columbia, Canada
- Nicolaou, Savvas, Vancouver General Hospital, Vancouver, British Columbia, Canada
Background
Gout prevalence is about 1-5% in the western world, predominantly in elderly men. Monosodium urate (MSU) deposition outside extremities has been scarcely investigated yet may be a potential indicator of tophus burden and impending clinical deterioration.
Methods
After IRB approval, retrospective single center analysis of all Dual Energy CT abdomen and pelvis scans from January 2007 to July 2018 was conducted. The inclusion criteria were: age > 50 years, gout asymptomatic with high or normal uric acid level. All cases were then assessed by two radiologists using a validated software. The study was divided into two sub-cohorts based on gender, and assessed along three main parameters: aortic, other vascular (e.g. renal, iliac ..etc) and lumbar deposits.
Results
351 cases met the inclusion criteria (197 males, 56% and 154 females, 43.9%). Aortic, other vascular and spinal deposits were detected in 20.2%, 21.7% and 5.1% respectively. A statisical significant association between gender and gout deposits in all the three groups was detected with deposists more prevalent in men than women in all groups (27.4%, 31.5% and 7.6% for men and 11.0%, 9.1% and 1.9% for women in abdominal aorta, other vessels and lumbar spine respectively).
Regression analyis showed that uric acid levels cannot predict aortic deposits in neither men (p = 0.91) nor women (p= 0.198) groups. On the other hand, uric acid level can significantly predict other vascular deposits in women only (r=0.005, p= 0,003) and the spinal deposits in both men (r= 0.01, p= 0.003) and women (r=0.002, p= 0.037) groups.
Study limitations include retrospective analysis and feasibility sample.
Conclusion
MSU CT mapping was positive in gout-asympomatic patients with normal or high uric acid levels and are more prevalent in men than women. Uric acid level cannot predict aortic deposits but can predict other vascular deposits in women only and spinal deposits in both men and women.