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Abstract: FR-PO1016

Association of Pulse Pressure and Double Product with Cardiovascular and All-Cause Mortality in the LURIC Study

Session Information

Category: Hypertension and CVD

  • 1402 Hypertension and CVD: Clinical, Outcomes, and Trials

Authors

  • Krämer, Bernhard K., University Hospital Mannheim, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany
  • März, Winfried, Synlab Holding Deutschland GmbH, Mannheim, Germany
  • Yazdani, Babak, University Hospital Mannheim, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany

Group or Team Name

  • LURIC Study Group
Background

Systolic (SBP) and diastolic blood pressure (DBP) as well as mean arterial pressure (MAP) are already known as important predictors respectively risk factors for cardiovascular mortality. Pulse pressure (PP) is considered as an easily available marker of vascular stiffness and the double product (DP; SBP x heart rate (HR)) as a marker of cardiac workload. Therefore, we extended our analysis of outcome parameters by use of PP and DP.

Methods

We retrospectively analysed data from the Ludwigshafen Risk and Cardiovascular Health (LURIC) study, in which 3316 patients underwent coronary angiography.

Results

Long-term data from 3316 patients undergoing coronary angiography showed that by increasing SBP by 1mmHg the risk of both cardiovascular and all-cause mortality rose by 0.9 %. However, there was no significant relationship between DBP and mortality. A higher PP of 1 mmHg resulted in a higher cardiovascular mortality risk of 1.6 % and an all-cause mortality risk of 1.7 %. Increasing DP by 100 mmHg/min was associated with a 1.0 % higher risk of cardiovascular mortality and 0.9 % higher risk of all-cause mortality.

Conclusion

We provide evidence that not only the classic standard blood pressure parameters SPB and MAP predict cardiovascular mortality, but also that PP and DP are powerful predictors of cardiovascular and all-cause mortality in a cardiovascular risk population. PP and DP are superior predictors of a higher cardiovascular mortality in heart failure patients.