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Abstract: TH-PO721

Real World, Hard Outcomes, and Sex Differences in AKI

Session Information

Category: Women’s Health and Kidney Diseases

  • 2000 Women’s Health and Kidney Diseases

Authors

  • Acosta-Ochoa, Maria Isabel, Hosptal Clinico Universitario, Valladolid, Spain
  • Coca, Armando, Hosptal Clinico Universitario, Valladolid, Spain
  • Mendiluce, Alicia, Hosptal Clinico Universitario, Valladolid, Spain
Background

Several studies focus on sexual dimorphism when suffering AKI, some of them report that women could be a protected against adverse events. We compared hard clinical outcomes between females and males in a real world cohort with AKI.

Methods

Retrospective cohorts study of hospitalized patients with diagnosis of AKI. We used KDIGO-2012 criteria for stratifying AKI severity, analyzed epidemiological and clinical variables and compared clinical outcomes: length of hospital stay, need for dialysis, dialysis dependence, and renal recovery.

Results

We included 1269 cases, 70% male, DM 42%, and CKD 61%. Table 1A shows clinical variables and Table1B results between groups. We found that mean Charlson’s was higher in male individuals and women are hospitalized more frequently in medical wards. We found no statistically significant differences in hard clinical outcomes except for dialysis dependence at discharge (more in male individuals). We studied the effect of sex on death was using Cox regression analysis, univariate analysis revealed that sex was not a significant risk factor for death during AKI [HR (sex): 1.01, 95%CI: 0.78-1.30, p=0.95]; multivariate analysis including sex and AKI severity yielded similar results [HR (sex): 0.99, 95%CI: 0.77-1.29, p=0.98].

Conclusion

Experimental studies observe clear differences in clinical outcomes between genders when suffering AKI, some even concluding that female sexual hormones could be not only protective but also a possible treatment. In this real world study we observed a higher incidence of AKI in men than in women, consistent with previous larger epidemiological studies, and we only found that males are more frequently dialysis dependent at discharge. So we observed that women that suffer an AKI episode are not protected against it`s deleterious effects.

Table 1 A and B. Features and Results.