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Abstract: TH-PO991

FSGS Outcome Comparison: Idiopathic Collapsing Glomerulopathy vs. Not Otherwise Specified Variant

Session Information

Category: Glomerular Diseases

  • 1203 Glomerular Diseases: Clinical, Outcomes, and Trials

Authors

  • Luvizotto, Mateus Justi, University of Sao Paulo, Sao Paulo, Brazil
  • Sales, Gerard F., University of Sao Paulo, Sao Paulo, Brazil
  • Dias, Cristiane B., University of Sao Paulo, Sao Paulo, Brazil
  • Figueiredo, Giulia gabriela Borges, University of Sao Paulo, Sao Paulo, Brazil
  • Resende, Aline Lazara, University of Sao Paulo, Sao Paulo, Brazil
  • Malheiros, Denise M., University of Sao Paulo, Sao Paulo, Brazil
  • Neves, Precil D., University of Sao Paulo, Sao Paulo, Brazil
  • Yu, Luis, University of Sao Paulo, Sao Paulo, Brazil
  • Woronik, Viktoria, University of Sao Paulo, Sao Paulo, Brazil
  • Jorge, Lectícia, University of Sao Paulo, Sao Paulo, Brazil
Background

Focal segmental glomerulosclerosis (FSGS) is a morphologic pattern of glomerular injury that frequently progresses to end-stage renal disease. Histologic variants express variable rates of progression. Collapsing Glomerulopathy (CG) has usually been associated with poor renal outcomes, while the not otherwise specified (NOS) variant has better outcomes. The goal of this study was to compare the two histologic forms and identify clinical features of progression.

Methods

A retrospective analysis was performed on all CG and NOS cases diagnosed by kidney biopsy between 1996 and 2016 at the University of Sao Paulo. Clinical and laboratory data were collected at baseline and at the end of follow up. We excluded cases chronic viral infection, drugs, any suspected immune-mediated disease and diabetes. We analyzed histological, clinical and follow-up data and compared among variants. Outcome was defined as ESRD or doubling of baseline creatinine.

Results

Clinical features of the groups CG and NOS are summarized in Table 1. There was no significant difference in age, gender, albumine, hemoglobin, hematuria, proteinuria, among the two groups. The immunofluorescence of the renal biopsies showed a greater predominance of IgM and C3 in the CG compared to the NOS variant. The NOS form was significantly associated with a better renal outcome.

Conclusion

The collapsing and NOS variants had similar baseline CKD-EPI, however the collapsing form had a worse renal outcome. Moreover, Further studies are necessary to explore the different immunofluorescence patterns among the forms.