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Abstract: TH-OR070

Is Tissue Sodium Storage Driving Systemic Inflammation in CKD? A Sodium Magnetic Resonance Imaging Study

Session Information

Category: Fluid and Electrolytes

  • 902 Fluid and Electrolytes: Clinical

Authors

  • Akbari, Alireza, London Health Sciences Centre, London, Ontario, Canada
  • Hur, Lisa, Western University, London, Ontario, Canada
  • Penny, Jarrin D., London Health Sciences Centre, London, Ontario, Canada
  • Qirjazi, Elena, Alberta Health Sciences, Calgary, Alberta, Canada
  • Salerno, Fabio R., Western University, London, Ontario, Canada
  • McIntyre, Christopher W., London Health Sciences Centre, London, Ontario, Canada
Background

Tissue sodium accumulation is intimately related to immune system function, and has been shown to occur in CKD patients due to impaired sodium elimination. However, the systemic effects of sodium accumulation, such as malnutrition and inflammation, have not been explored in man. The aim of this study was to investigate the associations of tissue sodium accumulation in a sample of healthy controls and CKD patients using noninvasive 23-sodium (23Na) magnetic resonance imaging (MRI).

Methods

Axial MR images of the lower leg were acquired in 10 controls and 35 CKD patients (eGFR 10-58 ml/min/1.73m2) on a 3T MRI. Proton images for anatomical reference and 23Na images for calculating mean tissue sodium concentration were acquired. Regions of interest included skin, pretibial tissue, bone, soleus, and gastrocnemius muscles (fig 1). Pearson correlation analysis between sodium concentration in different tissues and standard serum biomarkers was performed.

Results

Sodium concentration in all storage compartments was elevated in CKD patients relative to controls (data not shown), and significantly associated with serum albumin as a marker of malnutrition/inflammation complex (fig 2).

Conclusion

The negative association between serum albumin and tissue sodium concentration suggests that sodium accumulation may be a relevant factor driving systemic malnutrition/inflammation complex in the CKD population.