Abstract: FR-PO430
Retrospective Analysis of Serum Albumin and Other Biomarkers in Chronic Hemodialysis Patients Dialyzed with the Optiflux F180NR Dialyzer
Session Information
- Hemodialysis and Frequent Dialysis - III
November 08, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 701 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Ficociello, Linda, Fresenius Medical Care Renal Therapies Group, Waltham, Massachusetts, United States
- Li, Yisha, Fresenius Medical Care Renal Therapies Group, Waltham, Massachusetts, United States
- Mullon, Claudy, Fresenius Medical Care Renal Therapies Group, Waltham, Massachusetts, United States
- Costanzo, Mark, Fresenius Medical Care Renal Therapies Group, Waltham, Massachusetts, United States
- Kossmann, Robert J., Fresenius Medical Care North America, Waltham, Massachusetts, United States
Background
Optiflux® dialyzers are commonly used in US ESRD patients. Considering that low serum albumin (sALB) levels are associated with increased risk of mortality, albumin loss during hemodialysis (HD) should be minimized, especially in patients (pts) with hypoalbuminemia. A retrospective analysis was conducted to assess changes in sALB and other biomarkers in pts dialyzed with the Optiflux F180NR (OPTI).
Methods
In-center HD pts (n=284) treated with OPTI dialyzers for 6 months were analyzed. Pts maintained the same vascular access type and were without a diagnosis of liver disease or cancer. Changes in pre-dialysis (Pre-HD) labs at month 1 (M1) and month 6 (M6) were compared using paired t-tests. A sub-analysis of pts with hypoalbuminemia (sALB <3.5 mg/dL) was conducted.
Results
After 6-months of HD treatments, significant increases in mean sALB (0.07 g/dL), nPCR (0.05), and hemoglobin (0.42 g/dL) were observed with increased mean ultrafiltration volume (UFV) and adequacy (Table). A sub-analysis of 47 pts with hypoalbuminemia at M1 showed increases in sALB (0.36 g/dL) at M6 for 44 pts. Three pts had concomitant decreases in sALB (0.4 g/dL) and nPCR (0.44) during the same period.
Conclusion
During a 6-month follow-up, HD patients dialyzed with Optiflux F180NR dialyzers showed increased levels of serum albumin, nPCR, hemoglobin, ultrafiltration volume, and Kt/V.
| Month 1 (M1) Mean | Month 6 (M6) Mean | Difference | p-value* | |
| Pre-HD sAlb, in g/dL | 3.84 | 3.91 | 0.07 | < 0.0001 |
| Normalized protein catabolic rate (nPCR), in g/kg/day | 1.01 | 1.06 | 0.05 | 0.002 |
| Pre-HD Hemoglobin (Hgb), in g/dL | 10.66 | 11.08 | 0.42 | < 0.0001 |
| Ultrafiltration volume (UFV) in L | 2.57 | 2.67 | 0.10 | 0.03 |
| spKt/V | 1.64 | 1.68 | 0.04 | 0.01 |
* from paired t-test
Funding
- Commercial Support –