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Kidney Week

Abstract: SA-PO522

A Protective Role of Renalase in Nephropathy

Session Information

Category: Diabetic Kidney Disease

  • 601 Diabetic Kidney Disease: Basic

Authors

  • Wang, Feng, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China
  • Yin, Jianyong, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China
  • Kong, Yiwei, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China
  • Liu, Xuanchen, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China
  • Zhao, Ting, Shanghai Sixth People's Hospital, Shanghai, China
  • Wang, Niansong, Shanghai Sixth People's Hospital, Shanghai, China
Background

Renalase, a recently discovered secreted flavoprotein, exerts anti-apoptotic and anti-inflammatory effects against renal injury in acute and chronic animal models. However, whether Renalase elicits similar effects in the development of diabetic nephropathy (DN) remains unclear. The studies presented here tested the hypothesis that Renalase may play a key role in the development of DN and have therapeutic potential for DN.

Methods

Renalase expression was determined in human kidney biopsies with diabetic nephropathy. The role of Renalase in the development of diabetic nephropathy were examined using Renalase heterozygous knockout mice with db/db background and db/db mice with Renalase overexpression. In addition, the effects of Renalase on high glucose induced podocytes were investigated.

Results

Renalase was downregulated in human diabetic kidneys compared with healthy controls. Our data demonstrated that Renalase heterozygous knockout resulted in elevated albuminuria and increased renal mesangial expansion in db/db mice. However, overexpression of Renalase significantly ameliorated renal injury in db/db mice. Renalase could inhibit high glucose-induced podocyte injury in vitro.

Conclusion

This study suggested that Renalase protected against the progression of DN and Renalase may represent as a novel therapeutic target for the treatment of DN.