Abstract: TH-PO712
Outcome and Prognostic Factors in ESRD Patients with Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Interventions
Session Information
- Hypertension and CVD: Epidemiology, Risk Factors
November 07, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Hypertension and CVD
- 1401 Hypertension and CVD: Epidemiology, Risk Factors, and Prevention
Authors
- Ko, Byounghwi, Yonsei University College of Medicine, Seodaemungu, Seoul, Korea (the Republic of)
- Jung, Chan-Young, Yonsei University College of Medicine, Seodaemungu, Seoul, Korea (the Republic of)
- Jo, Wonji, Yonsei University College of Medicine, Seodaemungu, Seoul, Korea (the Republic of)
- Joo, Youngu su, Yonsei University College of Medicine, Seodaemungu, Seoul, Korea (the Republic of)
- Park, Jung Tak, Yonsei University College of Medicine, Seodaemungu, Seoul, Korea (the Republic of)
Background
Several risk factors have been recognized for acute coronary syndrome (ACS) undergoing percutaneous coronary interventions (PCI) in the general population. Risk factors for poor outcome in end stage renal disease (ESRD) patients differ from those who do not receive chronic dialysis. Although ESRD patients have been shown to be susceptible to cardiovascular diseases, the overall outcome and factors associated with prognosis is not well elucidated. Therefore, the characteristics and progress of ESRD patients who underwent PCI for ACS have been examined.
Methods
Retrospective analyses were conducted in ESRD patients who underwent PCI due to ACS from 1 January 2005 to 31 December 2018 at Yonsei University Health System, Seoul, South Korea. The patients were followed-up until 30th May, 2019. Demographic characteristics, laboratory parameter, echocardiographic findings, and dialysis related parameters at the time of PCI were collected.
Results
A total of 228 patients were included in the final analysis. The mean age was 66.9 ± 10.6 years, 146 (64.0 %) were male, and 82 (36.0 %) were being treated for diabetes. During a mean follow-up duration of 109.9 ± 94.8 months, 78 (34.2 %) cases of mortality were reported. When the patients were grouped into survivors and non-survivors, peripheral artery occlusive disease (PAOD) and left main coronary disease were more common among non-survivors. Echocardiographic ejection fraction (EF) and serum albumin levels were lower, while serum troponin T and CK-MB levels at the time of ACS were significantly higher among non-survivors. Multivariate logistic regression analysis revealed that concomitant PAOD (OR, 3.95; CI, 1.17-13.1), left main coronary disease (OR, 4.31; CI, 1.13-16.42), EF lower than 50% (OR, 8.30; CI, 1.84-37.41), lower serum albumin (OR, 4.29; CI, 1.44-12.79), and higher CK-MB (OR, 3.51; CI, 1.25-9.85) and troponin T levels (OR, 1.68; CI, 1.08-2.63) were significant factors related with in hospital mortality.
Conclusion
Outcome after PCI in ESRD patients with ACS was grave. Concomitant PAOD, echocardiographic findings, and cardiac enzyme levels could be practical factors predicting mortality in these patients.