Abstract: TH-PO633
Donor-Recipient Gut Microbiota Similarity and Allograft Function Early After Kidney Transplantation
Session Information
- Health Maintenance, Nutrition, Metabolism - I
November 07, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Bioengineering
- 300 Bioengineering
Authors
- Kim, Ji Eun, Seoul National University Hospital, Seoul, Korea (the Republic of)
- Cho, Hyunjeong, Chungbuk National University Hospital, Cheongju-si, Korea (the Republic of)
- Park, Ji In, Kangwon National University Hospital, Chuncheon-si,, Korea (the Republic of)
- Yang, Seung Hee, Kidney Research Institute, Seoul National University, Seoul, Korea (the Republic of)
- Lee, Jung Pyo, Seoul National University Boramae Medical Center, Seoul, Korea (the Republic of)
- Kim, Dong Ki, Seoul National University Hospital, Seoul, Korea (the Republic of)
- Lee, Hajeong, Seoul National University Hospital, Seoul, Korea (the Republic of)
- Kim, Yon Su, Seoul National University College of Medicine, Seoul, Korea (the Republic of)
Background
Gut microbiota affects the development and maintenance of innate and adaptive immune function. However, the effect of microbial composition similarity between recipient and donor on graft function after kidney transplantation (KT) remains unknown.
Methods
We prospectively enrolled living donor KT cases at two centers. Stool samples were obtained before KT. Microbiota composition was analyzed using extracted metagenomic DNA from the feces, using the Illumina MiSeq system. Gut microbiome difference between donor and recipient was calculated by weighted Unifrac distance. Clinical outcome was defined as 6 month post-transplant graft function.
Results
The microbial distance was estimated from 55 donor-recipient pairs. The recipients were 47.7 ± 13.0 years old; donors, 47.5 ± 11.2 years old. Among 26 related, 25 spousal and 4 unrelated donor transplants, couples showed lesser microbial composition difference than genetically related pairs. Spousal donors more frequently sharing meals with their recipients. The number of meals eating together in a day was significantly correlated with microbial distance. In terms of graft outcome, eGFR at 6 month after KT was significantly correlated with microbial distance (P=0.014). In addition, patients with the farthest quartile of microbial distance suffered from more rejection events in 6-month after KT.
Conclusion
In this study, we found that intestinal microbiome similarity between donor and recipient might affect allograft function early after KT.