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Abstract: SA-PO722

Brain Structural and Functional Dissociated Connectivity Patterns Between ESRD Patients with Peritoneal Dialysis and Hemodialysis

Session Information

Category: Pathology and Lab Medicine

  • 1602 Pathology and Lab Medicine: Clinical

Authors

  • Jun, Seong Myung, Haeundae paik hospital Inje University, Busan, Korea (the Republic of)
  • Lee, Yoo jin, Haeundae paik hospital Inje University, Busan, Korea (the Republic of)
  • Park, Bongsoo, Haeundae paik hospital Inje University, Busan, Korea (the Republic of)
  • Park, Sihyung, Haeundae paik hospital Inje University, Busan, Korea (the Republic of)
  • Kim, Yang Wook, Haeundae paik hospital Inje University, Busan, Korea (the Republic of)
Background

The aim of this study was to investigate and compare the alterations of structural and functional connectivity between peritoneal dialysis(PD) patients and hemodialysis (HD) patietnts.

Methods

We prospectively enrolled neurologically asymptomatic 20 maintenance PD patients, 20 maintenance HD patients and 40 healthy controls, and all of the subjects underwent diffusion tensor imaging (DTI) and resting state functional MRI (rs-fMRI) to investigate the alterations of structural and functional connectivity. We calculated the measures of structural and functional connectivity based on DTI and rs-fMRI, respectively. We assessed cognitive function in the patients with ESRD with the MMSE, MoCA, and CERAD neuropsychological battery.

Results

The main findings of our study were that PD patients had decreased global structural connectivity compared to healthy controls and HD patients had decreased global functional connectivity compared to healthy controls. In addition, we found that there are many regions in the alteration of local structural and functional connectivity between PD patients compared to healthy subjects and HD patients compared to healthy subjects.

Conclusion

We found that patients with ESRD had decreased structural and functional brain connectivity, and there are important differences of the structural and functional connectivity in brain networks according to the dialysis modality