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Kidney Week

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Abstract: TH-PO611

Association Between Vitamin D Level and Muscle Strength in Patients Undergoing Hemodialysis

Session Information

Category: Health Maintenance, Nutrition, and Metabolism

  • 1300 Health Maintenance, Nutrition, and Metabolism

Authors

  • Kang, Seok hui, Yeungnam University Hospital, Daegu, Korea (the Republic of)
  • LEE, YOUNSU, Yeungnam University Medical Center, Deagu, Korea (the Republic of)
  • Do, Jun-Young, Yeungnam University Hospital, Daegu, Korea (the Republic of)
  • Kim, Jun Chul, CHA Gumi Medical Center, CHA University, Gumi-si, Gyeongsangbuk-Do, Korea (the Republic of)
Background

Considering conflicting results or heterogeneity in study design, further investigations are needed to identify the definite association between vitamin D level and muscle health. Our study aimed to address these issues and to evaluate the association between vitamin D level and muscle mass indices, strength, or physical performance through comprehensive measurements in patients undergoing hemodialysis.

Methods

This study was performed in a tertiary medical center. We included patients undergoing hemodialysis with age ≥20 years. A total of 84 patients were enrolled. The patients were divided into tertiles based on the 25-hydroxy (25-OH) vitamin D level as follows: lowest tertile (Lowest T, n = 28), middle tertile (Middle T, n = 28), and highest tertile (Highest T, n = 28). We evaluated the association between the tertiles and clinical outcomes including nutritional status, muscle mass, muscle function, handgrip strength (HGS), physical performance, and health-related quality of life scales (HRQoL).

Results

There were no significant differences in the muscle mass indices and nutritional markers according to tertiles of 25-OH vitamin D level. However, 25-OH vitamin D level as a continuous variable or the tertile of 25-OH vitamin D level as a categorical variable was positively associated with HGS. Logistic and linear regression analyses showed a consistent superiority of the Highest T in HGS compared with the Lowest or Middle T. Although the statistical significance was weak, the scores of various physical performance tests and the HRQoL scales were the highest in the Highest T, among the 3 tertiles.

Conclusion

The present study demonstrated that serum vitamin D level is associated with HGS in patients undergoing hemodialysis regardless of muscle mass indices or nutritional status.