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Abstract: SA-PO805

Lipoprotein Abnormalities Are Associated with Mitochondrial Function and Intermuscular Adipose Tissue in Patients with CKD

Session Information

Category: Health Maintenance, Nutrition, and Metabolism

  • 1300 Health Maintenance, Nutrition, and Metabolism

Authors

  • Gamboa, Jorge, Vanderbilt University Medical Center, Nashville, Tennessee, United States
  • Peng, Dungeng, Vanderbilt University Medical Center, Nashville, Tennessee, United States
  • Alsouqi, Aseel, Vanderbilt University Medical Center, Nashville, Tennessee, United States
  • Roshanravan, Baback, University of California Davis, Davis, California, United States
  • Ikizler, Talat Alp, Vanderbilt University Medical Center, Nashville, Tennessee, United States
Background

Dyslipidemia such as increased LDL cholesterol and triglycerides levels, and decreased HDL levels frequently occurs in patients with CKD. There are limited data regarding the changes in lipoprotein composition and lipoprotein subfractions (based on density and size) in patients with CKD. Mitochondrial dysfunction may contribute to dyslipidemia and dyslipoproteinemia in patients with CKD including ectopic fat in skeletal muscle, i.e. intermuscular adipose tissue (IMAT). We now tested wheter lipoprotein abnormalities are associated with mitochondrial function and IMAT in patients with CKD.

Methods

In a cross-sectional study, we evaluated 63 patients (20 with CKD 3-4, 22 with CKD 5 on hemodialysis (HD), and 21 matched controls). Composition of lipoprotein subfractions was determined in plasma from proton nuclear magnetic resonance spectra (NMR). Mitochondrial function was evaluated by 31phosphorus magnetic resonance spectroscopy (31P-MRS). IMAT was evaluated in the quadriceps muscle using magnetic resonance images.

Results

Groups were matched by gender, body mass index, and history of diabetes and hypertension. We identified changes in lipoprotein composition in patients with CKD, particularly in the mature (the smallest and most dense) HDL subfraction 4 (HDL-4) including increased triglyceride content, loss of apolipoproteins (AI and AII), and a decrease in cholesterol (free and esterified) and phospholipids (Figure 1). Mitochondrial dysfunction was associated with HDL triglycerides content (ρ=0.47, p<0.001) and HDL-4 Apolipoprotein AII (ρ=-0.43, p=0.001). IMAT accumulation was associated with HDL triglycerides content (ρ=0.65, p<0.001) and HDL-4 phospholipids (ρ=-0.36, p=0.009).

Conclusion

HDL composition is altered in patients with CKD and it is associated with mitochondrial dysfunction and IMAT accumulation. Dysfunctional HDL is unable to efficiently remove lipids from peripheral tissues and may contribute to IMAT accumulation. Likewise, changes in HDL apolipoproteins may affect mitochondrial function. Further studies should evaluate the interrelation among lipoproteins, mitochondrial function, and IMAT in patients with CKD.

Funding

  • NIDDK Support