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Abstract: TH-PO188

Oxidative Stress Is Associated with Overhydration and Sarcopenia in Hemodialysis Patients

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis

Authors

  • Kim, Cheolsu, Hallym University Sacred Heart Hospital, Anyang, Korea (the Republic of)
  • Kim, Sung gyun, Hallym University, Anyang, Korea (the Republic of)
  • Lee, Hyungseok, Hallym University Sacred Heart Hospital, Anyang, Korea (the Republic of)
  • Joo, Narae, Hallym University Sacred Heart Hospital, Anyang, Korea (the Republic of)
  • Kim, Hyung jik, Hallym University Sacred Heart Hospital, Anyang, Korea (the Republic of)
Background

Increased oxidative stress is regarded as an important nontraditional risk factor in patients undergoing hemodialysis (HD). However, studies examining the long-term effect of oxidative stress by direct measurement of these markers and its association with volume status and sarcopenia are limited.

Methods

In this longitudinal observational study, serum protein carbonyl levels were measured in 88 stable HD patients. Additionally, multifrequency body composition analysis and handgrip strength (HGS) and nutritional assessments were performed and followed prospectively for up to 6 years.

Results

The mean patient age was 60.6 ± 13.5 years, and the mean HD duration was 50.8 ± 41.3 months. In total, 16 patients (18.2%) were overhydrated, 49 (55.7%) had low HGS and 36 (40.9%) had low muscle mass. Serum protein carbonyl levels were associated with serum levels of albumin, prealbumin and transferrin, hydration status and low HGS. Overhydration, prealbumin, subjective global assessment score and sarcopenia were significant predictors for serum protein carbonyl levels in the highest quartile. Multivariate analysis showed that the serum levels of protein carbonyl, albumin, prealbumin, overhydration and sarcopenia were independent determinants of all-cause and cardiovascular mortality. (Figure 1.)

Conclusion

Serum protein carbonyl was significantly associated with overhydration, nutritional status and sarcopenia and could be an important predictor of long-term outcomes in patients undergoing HD