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Abstract: SA-PO1061

The Effect of Dialysis on Aryl Hydrocarbon Receptor Binding Activities in Patients with CKD

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis

Author

  • Lee, So-young, Eulji University Hospital, Seoul, Korea (the Republic of)
Background

Persistent organic pollutants (POPs) are well-known endocrine disrupting chemicals reported to be associated with various metabolic diseases. We hypothesized that POPs levels are increased in patients with chronic kidney disease or undergoing dialysis, thus further complicating the disease course. In this study, we measured serum POPs levels using a highly sensitive cell-based arylhydrocarbon receptor (AhR) dependent luciferase activity (CALA) assay in end stage renal disease (ESRD) patients undergoing dialysis or not, and compared differences between patients.

Methods

Patients undergoing peritoneal dialysis(22), hemodialysis(38) for at least 36 months, and and intracellular ATP levels were measured and compared according to treatment modality. We performed a correlation analysis between AhR binding activities and ATP levels and various clinical parameters.

Results

AhR binding activities differed significantly between groups, AhR binding activity was higher in non-dialysis CKD patients, compared to patients undergoing dialysis, and higher in patients undergoing hemodialysis compared to peritoneal dialysis. AhR binding activities decreased after hemodialysis treatment in HD patients. ATP level was the higher in healthy controls, compared to pre-dialysis CKD patients, and patients with peritoneal dialysis and hemodialysis. AhR binding activities and intracellular ATP levels showed significant correlations with multiple clinical parameters associated with cardiovascular risk factors.

Conclusion

POPs were associated with chronic kidney disease, and ESRD, while dialysis treatment
reduced POPs levels. Further studies are mandated to specify the AhR binding activities and to
evaluate the exact role in patients with chronic kidney disease