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Abstract: FR-PO438

Relationship Between Serum Uric Acid and Vascular Calcification in Patients Treated with Hemodialysis

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis

Authors

  • Luo, Qimei, Shunde Hospital of Southern Medical University, Foshan, China
  • Dou, Xianrui, Shunde Hospital of Southern Medical University, Foshan, China
Background

Vascular calcification (VC) is highly prevalent among hemodialysis (HD) patients and predicts cardiovascular mortality. The level of serum uric acid (SUA) may be related with endothelial dysfunction, which may involve in VC. However, whether uric acid concentrations are associated with VC in HD patients is unknown. The aim of our study was to assess the association of SUA and VC in HD patients.

Methods

This was a cross-sectional study including 313 patients receiving HD therapy for at least 3 months between January 2014 and December 2018. The simple vascular calcification score (SVCS) in plain X-rays of the pelvis and hands was used to evaluate VCs.

Results

Mean age was 57.1±14.0 (SD) years, and 32.2% had diabetes. Mean uric acid level was 476.06±111.68 umol/L, 73.8% had hyperuricemia. The SVCS detected VC in 179 (57.1%) patients, including 160 patients presenting VC of pelvis arteries and 95 patients presenting VC of hands arteries. In total of patients, a SVCS≥ 3 was present in 104 (33.2%) patients. By binary logistic regression, age (P<0.001), HD duration (P<0.001), diabetes (P<0.001) were independently associated with a SVSC≥ 3, the levels of SUA was not associated with a SVSC≥ 3. Adjusted logistic regression models showed that the ORs per 1umol/L higher uric acid level for VC of pelvis arteries was 0.996 (95% CI, 0.994-0.999; P=0.015) in total patients and 0.995 (95% CI, 0.991-0.999; P=0.010) in non-diabetic HD patients. However, there was no association between SUA and VC of hands arteries.

Conclusion

Higher uric acid levels were associated with lower risk of VC of pelvis arteries in patients treated with HD.