Abstract: TH-PO1005
Significant Intestinal Flora Disturbance Is Discovered in IgA Nephropathy Patients
Session Information
- Glomerular Diseases: Minimal Change Disease, FSGS, IgAN
November 07, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1203 Glomerular Diseases: Clinical, Outcomes, and Trials
Authors
- Zhong, Zhengxia, Affiliated Hospital of Zunyi Medical University, Guizhou, China, Zunyi, guizhou province, China
- Tan, Jiaxing, West China Hospital of Sichuan University, Chengdu, Sichuan, China
- Qin, Wei, West China Hospital of Sichuan University, Chengdu, Sichuan, China
- Tan, Li, West China Hospital , Chengdu, China
- Yang, Yibing, Affiliated Hospital of Zunyi Medical University, Guizhou, China, Zunyi, guizhou province, China
Background
IgA nephropathy (IgAN) is an autoimmune glomerular disease, manifested by hematuria with or without proteinuria. The pathogenesis has not been clarified yet. This study investigated the relationship between IgAN and gut microbiota composition to understand gut-kidney axis.
Methods
44 patients with biopsy-proven IgAN and 15 healthy controls were enrolled. The patients were divided into two groups based on levels of urine red blood cells (uRBC). Compositions of intestinal flora were assessed by 16sRNA microbial profiling approach.
Results
The proportions of Escherichia-Shigella (5.16%±8.25% vs 0.83%±1.12%, P=0.04) and Bacteroides (19.9%±16.34% vs 9.20%±6.21%, P=0.02) increased significantly in IgAN patients, compared with normal control. Conversely, Bifidobacterium (1.29%±3.51% vs 4.07%±7.62%, P=0.06), Eubacterium hallii (1.16%±2.07% vs 3.36%±3.78%, P=0.01) and Megamonas (2.36%±7.67% vs 13.2%±25.7%, P=0.01) was markedly decreased. Subgroup analysis indicated patients with higher level of uRBC tended to have higher rates of Escherichia-Shigella (6.93%±9.48% vs 1.27%±1.67%, P=0.02) and Faecalibacterium (11.16%±7.73% vs 5.77%±4.42%, P=0.02), compared with lower uRBC group. Moreover, the levels of Bifidobacterium were not detected in 72.9% IgAN patients. Interestingly, the patients lack of Bifidobacterium were more likely to have lower level of eGFR (87.49±34.50 vs 104.64±13.67, P=0.03) and higher level of uric acid (398.93±135.26 vs 300.56±93.19, P=0.05), suggesting that Bifidobacterium might have potential renoprotective effects and its loss might contribute to the progression of IgAN.
Conclusion
IgAN are featured by increase in pathogenic bacteria and reduction of beneficial bacterium. Potential intestinal flora disturbance might be related to the occurrence of IgAN, which could become a new therapeutic target.