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Kidney Week

Abstract: TH-PO614

A Pilot Study on Association of Arterial Stiffness with Dynapenia and Sarcopenia in Hemodialysis Patients

Session Information

Category: Health Maintenance, Nutrition, and Metabolism

  • 1300 Health Maintenance, Nutrition, and Metabolism

Authors

  • Kumar, Rajesh B., Apex Kidney Care, Mumbai, India
  • Dedhia, Paras, Apex Kidney Care, Mumbai, India
  • Jasani, Rachana H., Apex Kidney Care, Mumbai, India
  • Kothari, J., Hinduja Hospital,Healthcare & Apex Kidney Foundation, Mumbai, India
  • Bichu, Shrirang, Bombay Hospital, Mumbai, India
  • Billa, Viswanath, Bombay Hospital, Mumbai, India
  • Gupta, Virendra, Apex Kidney Care, Mumbai, India
  • Mohd shah, Alam, Apex Kidney Care, Mumbai, India

Group or Team Name

  • Apex Kidney Care
Background

Low muscle strength (dynapenia) and low muscle strength plus low skeletal muscle mass (sarcopenia) are often found to be coexisting with obesity in chronic hemodialysis patients. As arterial stiffness is directly related to cardiovascular mortality, it was of interest to study its association with dynapenic obesity (DO), sarcopenic obesity (SO) in this population.

Methods

Arterial stiffness was estimated from brachial cuff-based oscillometric device Mobil-O-Graph. Body Composition Analysis through bioelectrical impedence was utilized to assess body fat and lean tissue index (LTI). Muscle strength was determined using handgrip strength (HGS) analysis. Dynapenia was defined by HGS <26 kg for men and < 18 kg for women. Sarcopenia was defined as LTI <10.7 kg/m2 in men and <6.7 kg/m2 in women. Obesity was defined as percent body fat > 25% in men and > 35% in women.

Results

Of 206 patients, 124 were males. Their average age was 55.3± 15.4 years and average dialysis vintage was 2.8±2.7 years. All patients were on thrice a week hemodialysis. Of 206 patients, 44% were diabetic, 58% were hypertensive and 29% had ischemic heart disease.The prevalence of dynapenia was 87.8% and that of sarcopenia was 42.7%. Prevalence of DO and SO was 19.4% and 14.5% respectively. The prevalence of arterial stiffness in patients with DO was 72.5% and that in patients with SO was 70%.

Conclusion

Prevalence of arterial stiffness is high in patients with DO and SO. Further studies are needed to evaluate interventions for reducing dynapenic and sarcopenic obesity and their impact on reduction in arterial stiffness inorder to reduce cardiovascular mortality.