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Abstract: SA-PO147

Hypoalbuminemia Is Related with Short-Term and Long-Term Mortality in Patients Undergoing Continuous Renal Replacement Therapy

Session Information

Category: Acute Kidney Injury

  • 102 AKI: Clinical, Outcomes, and Trials

Authors

  • Moon, Jong joo, Seoul National University Hospital, Seoul, Korea (the Republic of)
  • Kim, Yaerim, Seoul National University Hospital, Seoul, Korea (the Republic of)
  • Joo, Kwon Wook, Seoul National University Hospital, Seoul, Korea (the Republic of)
  • Kim, Yon Su, Seoul National University College of Medicine, Seoul, Korea (the Republic of)
  • Han, Seung Seok, Seoul National University College of Medicine, Seoul, Korea (the Republic of)
Background

Hypoalbuminemia reflects several pathologic conditions such as nutritional deficiency and chronic inflammation. However, its relationship with short-term and long-term mortality in patients undergoing continuous renal replacement therapy (CRRT) remains unresolved.

Methods

A total of 1,581 patients who underwent CRRT due to acute kidney injury between 2010 and 2016 were retrospectively reviewed. Patients were categorized by the tertiles of albumin levels at the time of starting CRRT. Odds ratio (OR) and hazard ratio (HR) for the risk of all-cause mortality were calculated before and after adjustment of multiple covariates.

Results

Mean albumin level was 2.7 ± 0.6 g/dL. During the median follow-up period of 14 days (maximum 4 years), 1,040 patients (65.8%) died. The 1st tertile had a higher risk of mortality than the 3rd tertile with an HR of 1.9 (1.63–2.21). Although the mortality rate was stratified by the timeframe, the 1st tertile had a higher risk than the 3rd tertile as following ORs: 3.0 (2.34–3.87) in 2-week mortality; 2.7 (2.12–3.52) in 1-month mortality; 2.7 (2.08–3.53) in 6-month mortality; and 2.8 (2.11–3.62) in 1-year mortality. The 1st tertile group had also higher rates of intensive care unit- and in-hospital mortalities than the 3rd tertile group.

Conclusion

Because hypoalbuminemia is associated with short-term and long-term mortality after CRRT, serum albumin levels should be monitored during the period of CRRT.