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Kidney Week

Abstract: TH-PO413

Prevalence of Kidney Failure Among Adult Population in Madagascar

Session Information

Category: CKD (Non-Dialysis)

  • 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

  • Mikkelsen, Ranivoharisoa Eliane, University Hospital of Befelatanana, Antananarivo, Madagascar
  • Raherinandrasana, Antso hasina, University Hospital of Care and Public Health Analakely, Antananarivo, Madagascar
  • Massy, Ziad, Ambroise Pare University Hospital and Inserm U1018 Eq5, Boulogne Billancourt/ Paris cedex, France
  • Rakotonirina, Julio, University Hospital of Care and Public Health Analakely, Antananarivo, Madagascar
  • Randriamarotia, Harilalaina Willy franck, University Hospital of Befelatanana, Antananarivo, Madagascar

Group or Team Name

  • Befelatanana Neprology's Team
Background


Kidney Failure becomes a public worldwide health problem mainly in a developing country. Few data is available in most of countries in Africa to specify the prevalence of CKD. We assessed the prevalence and risk factors of kidney failure among population in Madagascar.

Methods

We conducted a randomized, multicenter, cross sectional study among four provinces in the Island. It includes Tananarive, Majunga, Fianarantsoa and Tamatave. Kidney function was evaluated by capillary creatinine using strip test and creatinine meter. We defined kidney failure if the glomerular filtration rate calculated with the Equation of Chronic Kidney Disase Epidemiology was under than 60ml/mn/1,73m2. Cluster sample was used to characterise the study population.

Results

A total of 808 patients were included. Prevalence of kidney failure was 12.5%. Mean age was 38 years old (+/-15). Sex-ratio was 0,84. Patients were aged 25-55 years old in 62,1%. Normal socioeconomic class was found in 64% of the cases. Hypertension and diabetes were identified respectively in 30,3% and 7,7% in studied population. During screening, mean creatinine level was 99µmol/l (+/-25) and mean post prandial glycemia was 1,16g/dl (+/-0,3). According to KDIGO classification, patients were classified in Stage 3, 4 and 5 of CKD respectively in 10,76%(N=87), 0,7 % (N=6) and 1% (N=8). In mono variable analysis, kidney failure was related with gender (p =0,078), age(p =0,0001), socioeconomic class (p=0,005), familial back ground of hypertension (p =0,04), personnel back ground of hypertension (p <0,0001) and diabetes (p =0,05), the level of blood pressure during examination (p=0,088), glycemia (p = 0,003) and body mass index (p = 0,003). In Multiple variable analysis, it was related with female gender (OR =0,57; IC =0,35-0,92), age > 54 years old (OR =14,04 ; IC =5,25-37,5), rich socio economic class(OR =2,8; IC =1,03-7,81), overweight (OR =2,5 ; IC =1,08-4,92) and obesity (OR =2,5 ; IC =1,13-5,73)

Conclusion

This is the first study in Africa which evaluates the kidney failure by using creatinine strip test. The prevalence is high compare another african countries. Almost of the patients were seen lately over Stage 3 of CKD requiring a specialized medical follow-up. Prevention of all risk factors should be first of all the best solution.