ASN's Mission

ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005


The Latest on Twitter

Kidney Week

Abstract: SA-PO342

Lanosterol Synthase (LSS) Gene as a Predictor of Kidney Dysfunction in Hypertensive Patients

Session Information

Category: Hypertension and CVD

  • 1403 Hypertension and CVD: Mechanisms


  • Simonini, Marco, San Raffaele Scientific Institute, Milan, MILANO, Italy
  • Citterio, Lorena, San Raffaele Scientific Institute, Milan, MILANO, Italy
  • Salvi, Erika, Istituto Besta, Milan, Italy
  • Lanzani, Chiara, San Raffaele Scientific Institute, Milan, MILANO, Italy
  • Messaggio, Elisabetta, San Raffaele Scientific Institute, Milan, MILANO, Italy
  • Fontana, Simone, San Raffaele Scientific Institute, Milan, MILANO, Italy
  • Cusi, Daniele, Bio4Dreams LifeSciences Incubator, Bresso, Italy
  • Manunta, Paolo, San Raffaele Scientific Institute, Milan, MILANO, Italy

Hypertension (HYP) is one of the main causes of chronic kidney disease (CKD). Recently we have proposed LSS as genotype-based risk stratification to predict accelerated eGFR decay in essential HYP patients. We tried to find a confirmation of this result in an observational study on general population.


We extracted clinical data of a general population from HYPERGENES Consortium. We also collected genetic data for LSS polymorphism that was already demonstrated as involved in kidney damage.


A cohort of 3137 subjects was selected. Incidence of HYP and CKD was 49.8% and 9.1% respectively. Patients with well-known no-HYP / no-angiosclerosis related CKD (as diabetes, glomerulonephritis, ADPKD), were excluded. Population was divided into 3 classes according to age.
At different age, HYP status have a deep impact on eGFR. Indeed in young (< 50ys) eGFR is higher in HYP vs control (86.2±19.3 vs 82.7±16.3 ml/min; p=0.04); vice-versa in elder (> 65ys) HYP have a reduction in eGFR (55.7±12.9 vs 71.0±12.9 ml/min; p<0.001). No direct influence of LSS polymorphism on eGFR was observed. When LSS is considered according to HYP status and age class it is possible to observe a preservation of age-associated eGFR reduction in normotensive patients (eGFR 91.4 vs 90.1 vs 81.8 ml/min for LSS risk allele); on the other side, LSS seems to enhance eGFR reduction associated with HYP status (eGFR 84.6 vs 75.6 vs 48.0 ml/min for LSS risk allele; p=0.032; fig. 1).


We confirmed on a large general population the involvement of LSS gene in enhanced eGFR loose in HYP patients. Indeed patients carrying the risk allele of this specific LSS polymorphism seem to express hyper-filtration if compared to their counterparts. When exposed to a specific pathological condition as HYP, with a further increase in eGFR in early phases, this could lead to an accelerated reduction in kidney function.