Abstract: TH-PO680
Association Between Geriatric Nutritional Risk Index (GRNI) and the Increased Risk for Stroke in Patients Receiving Hemodialysis: Ten-Year Outcome of the Q-Cohort Study
Session Information
- Hypertension and CVD: Epidemiology, Risk Factors
November 07, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Hypertension and CVD
- 1401 Hypertension and CVD: Epidemiology, Risk Factors, and Prevention
Authors
- Tsuneyoshi, Shoji, Kyushu university , Fukuoka, Japan
- Matsukuma, Yuta, Kyushu University, Fukuoka City, FUKUOKA, Japan
- Hiyamuta, Hiroto, Kyushu University, Fukuoka City, FUKUOKA, Japan
- Yamada, Shunsuke, Kyushu University, Fukuoka City, FUKUOKA, Japan
- Kitazono, Takanari, Department of Medicine and Clinical Science, Fukuoka, Japan
- Tsuruya, Kazuhiko, Nara Medical University, Kashihara, Japan
- Nakano, Toshiaki, Kyushu University, Fukuoka City, FUKUOKA, Japan
Background
Geriatric nutritional risk index (GRNI), a useful tool for the evaluation of nutritional status, is associated with increased risk for cardiovascular events in hemodialysis patients. Few studies have examined the association between GNRI level and the incidence of stroke in patients receiving hemodialysis.
Methods
A total of 3047 patients registered to the Q-Cohort Study, a multicenter, prospective observational cohort of hemodialysis patients, were examined. The main outcomes were the development of brain hemorrhage and infarction. The main exposure was GNRI, calculated by serum albumin level and body mass index. Patients were divided into quartiles based on the baseline GNRI level; Q4：>99.8, Q3：95.6-99.8, Q2：90.7-95.5, Q1：<90.7. The risks for either brain infarction or hemorrhage were estimated by multivariable-adjusted Cox proportional hazard risk models.
Results
During the follow-up period of 10 years, 149 patients developed brain hemorrhage and 326 patients developed brain infarction. Cox proportional hazard risk models showed that the risks for brain hemorrhage and infarction in Q1 were significantly higher than that in Q4 group: hazard ratio [95% confidence interval], 1.69 [1.19-2.42] and 1.85 [1.08-3.16], respectively. Furthermore, restricted cubic spline curves showed that a lower GNRI was incrementally associated with an increased risk for both brain hemorrhage and infarction.
Conclusion
Our results suggest that lower GNRI is a risk factor for brain hemorrhage and infarction in maintenance hemodialysis patients.