Kidney Week

Abstract: FR-PO356

Impact of Periostin in Aging Kidney

Session Information

• CKD: Mechanisms - II
  November 08, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2103 CKD (Non-Dialysis): Mechanisms

Authors

• Ryoo, Jiwon, Seoul St. Mary's Hosp, Catholic Univ of Korea, Seoul, Korea (the Republic of)

Jiwon Ryoo,

• Kwon, Yun Jae, Seoul St. Mary's Hosp, Catholic Univ of Korea, Seoul, Korea (the Republic of)

Yun Jae Kwon,

• Kim, Hyung Duk, Seoul St. Mary's Hosp, Catholic Univ of Korea, Seoul, Korea (the Republic of)

Hyung Duk Kim,

• Kim, Eun Nim, The Catholic University of Korea, Seoul, Korea (the Republic of)

Eun Nim Kim,

• Jin, Yongjie, The Catholic University of Korea, Seoul, Korea (the Republic of)

Yongjie Jin,

• Lim, Ji Hee, The Catholic University of Korea, Seoul, Korea (the Republic of)

Ji Hee Lim,

• Kim, Yaeni, Seoul St. Mary's Hosp, Catholic Univ of Korea, Seoul, Korea (the Republic of)

Yaeni Kim,

• Park, Cheol Whee, Seoul St. Mary's Hosp, Catholic Univ of Korea, Seoul, Korea (the Republic of)

Cheol Whee Park,

• Choi, Bumsoon, Division of Nephrology, Department of Internal Medicine, Seoul, Korea (the Republic of)

Bumsoon Choi,

Background

Periostin is a matricellular protein which plays important role in tissue adaptation to injury. In kidney disease, periostin is known to be highly expressed in tubulointerstitial fibrosis and correlated with renal function inversely. In this study, we investigated the effect of periostin in aging process and progressive renal interstitial fibrosis.

Methods

1. UUO model
We conducted unilateral ureteral obstruction (UUO) surgery in wild type (WT) mice and periostin knockout (KO) mice. And compared interstitial fibrosis and pericyte changes.

2. Aging model
We compared interstitial fibrosis and changes of pericytes in 4 groups; WT young age group, WT old age group, periostin KO young age group and periostin KO old age group.

Results

In UUO model, periostin KO mice shows less interstitial fibrosis and increased number of pericytes.
And periostin KO aging mice shows attenuated fibrosis and abundant pericytes compared to WT aging mice.

Conclusion

Periostin inhibition ameliorated renal interstitial fibrosis in UUO model and aging process. It is thought that it affects pericyte and shows a reno-protective effect.

Figure 1. Changes of pericytes in UUO of periostin KO mouse

Figuer 2. Changes of fibrosis and pericytes in aging periostin KO mouse