Kidney Week

Abstract: TH-PO1130

Donor Kidney Renal Volume Predicts Recipient and Donor Graft Function at 1 Year

Session Information

• Transplantation: Clinical - Predictors of Outcomes - Biomarkers and Beyond
  November 07, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Transplantation

• 1902 Transplantation: Clinical

Authors

• Ebad, Chaudhry Adeel, Beaumont Hospital, Dublin, Ireland

Chaudhry Adeel Ebad,

• Chevarria, Julio L., Beaumont Hospital, Dublin, Ireland

Julio L. Chevarria,

• Sexton, Donal J., Beaumont Hospital, Dublin, Ireland

Donal J. Sexton,

• Brennan, David James, Beaumont Hospital, Dublin, Ireland

David James Brennan,

• Williams, Yvonne E., Beaumont Hospital, Dublin, Ireland

Yvonne E. Williams,

• O'Seaghdha, Conall M., Beaumont Hospital, Dublin, Ireland

Conall M. O'Seaghdha,

• Conlon, Peter J., Beaumont Hospital, Dublin, Ireland

Peter J. Conlon,

Background

Renal transplantation is treatment of choice in end stage renal disease of which Living donor kidney transplantation is optimal. The role of renal volume measurement in predicting long-term donor and recipient graft outcome is not clear.

Methods

This retrospective cohort study of living donor kidney transplantaion (2010-2017) from the National Kidney Transplant Service (NKTS) of Ireland. Renal volume was measured bilaterally in living kidney donors using TeraRecon USA. Low eGFR for recipients and donors defined as < 60ml/min 1-year post donation was used in logistic regression modeling with donor volume categorized into tertliles. Donor and recipient characteristics were included in the models as potential confounding variables.

Results

There were 166 living donor kidneys in the study period. Mean donor age was 44.8 years (SD = 10.8). Donor mean BMI was 25.5 (SD = 2.9). Donor kidney volume mean was 152.7 mls (SD = 31.6), divided into tertiles was; 1: 89.2 – 135 mls, 2: 136 – 164 mls, 3:165 – 240 mls. Median donor eGFR at 1 year post transplant was 63.3 (IQR² = 56.1 – 70.4).
Recipients of living donor kidneys had a mean age of 43.5 years (SD = 13.3) .Median recipient eGFR at 1 year post transplant was 58.3 (IQR = 48.4 – 69.4).
Donor kidney volume is slightly correlated with donor eGFR at 1 year post transplant (figure 1) and is marginally non significant in logistic regression for low eGFR using the above tertile categories; Odds Ratio 0.65 [95% conf. int. 0.40 – 1.04, p value = 0.075].
Donor kidney volume is correlated with recipient eGFR at 1-year post transplant (figure 1) and is significant in multivariable logistic regression; Odds Ratio 0.48 [95% conf. int. 0.26 – 0.90, p value = 0.021].

Conclusion

Donor kidney volume predicts recipient graft function 1-year post transplant but is less conclusive for donor kidney function. Cognizance of donor renal volume may help optimise potential kidney donor selection.

Figure 1: Correlation of renal volume and eGFR in donors and recipients at 1 year