Abstract: FR-PO640
Serum Magnesium, Mortality, and Cardiovascular Disease in CKD and ESRD Patients: A Systematic Review and Meta-Analysis
Session Information
- Fluid and Electrolytes: Clinical - Acid-Base, Magnesium, Calcium, Phosphorus
November 08, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Fluid and Electrolytes
- 902 Fluid and Electrolytes: Clinical
Authors
- Xiong, Jiachuan, Xinqiao hospital, Chongqing, China
- He, Ting, Department of Nephrology, Xinqiao Hospital, Chongqing, China
Background
Magnesium plays an independent pathogenic role in chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients. However, the results of these studies were somewhat underpowered and inconclusive.
Methods
Literature was identified by searching PubMed, EMBASE, Web of Science and the Cochrane Central Register of Controlled Trials (CENTRAL). Unadjusted and adjusted hazard ratios (HRs) with 95% confidence intervals (95% CIs) were pooled.
Results
The results showed that there was a strong association between hypomagnesemia and the risk of all-cause mortality in patients with CKD and ESRD (HR 1.32; 95% CI1.19–1.47; p < 0.00001) after multivariable adjusted. On the contrary, hypermagnesemia was inversely associated with all-cause mortality in patients with CKD and ESRD (HR 0.86; 95%CI 0.79–0.94; p = 0.001) . Moreover, a significant association between hypermagnesemia and decreased risk of cardiovascular mortality was observed (HR 0.71; 95% CI 053–0.97, p = 0.03) in the adjusted model. In addition,subgroup analysis found that hypomagnesemia was strongly associated with increased all-cause mortality in hemodialysis patients (HR 1.29; 95% CI 1.12–1.50; p = 0.0005).
Conclusion
Our results indicate that hypomagnesemia is significantly associated with cardiovascular and all-cause mortality
in patients with CKD and ESRD.
The association between hypomagnesemia and all-cause mortality for dichotomous variables (hypomagnesemia vs. normal magnesium or
hypermagnesemia group)
Fig.
The association between hypermagnesemia and all-cause mortality for continuous variables (hypermagnesemia vs. normal magnesium or
hypomagnesemia group)