Abstract: TH-PO402
The Histological Spectrum of CKD in HIV-Infected Black Patients: A Single-Centre Experience
Session Information
- CKD: Risk Scores and Translational Epidemiology
November 07, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Onu, Ugochi Chika, University of Nigeria Teaching Hospital Enugu, Enugu, Nigeria
- Adu, Dwomoa, University of Ghana, Accra, Ghana
- Ojo, Akinlolu O., University of Arizona Health Sciences, Tucson, Arizona, United States
- Ulasi, Ifeoma I., College of Medicine, University of Nigeria, Enugu, Nigeria
Group or Team Name
- H3Africa Kidney Disease Research Network
Background
HIV infection has become one of the world’s most serious health and developmental challenge affecting 36.9 million people. Kidney disease is the 4th most common cause of death among HIV-infected patients. HIV-Associated Nephropathy (HIVAN) has been documented as the most common cause of chronic kidney disease (CKD) in HIV-1seropositive patients. Although 9% of world’s HIV-infected patients live in Nigeria, data on spectrum of kidney diseases affecting HIV-infected patients are still paltry. The study was undertaken to determine the histological spectrum of CKDs in HIV-infected patients.
Methods
Fifty-eight adequate biopsy samples from 72 adult HIV- infected patients with ≥stage 3 CKD who underwent real time ultrasound guided kidney biopsy between April 2016 and August 2018 were studied using light microscopy and immunohistochemistry. Patients having diabetes mellitus, other viral infections, obstructive uropathies, other systemic diseases with renal involvement and malignancies were excluded.
Results
There were 25 (43.1%) males and 33 (56.9%) females. Participants were aged 21- 65 years. Mean age was 43.86± 9.83years. Forty- three (74.1%) patients had WHO clinical asymptomatic disease. Only 9/58(15.5%) patients had CD4 cell count < 200 cells/mm3. Histology showed 13(22.4%) HIVAN, 8(13.8%) normal histology and 37(63.8%) non-HIVAN lesions including: 12(20.7%) FSGS (NOS), 7(12.1%) focal global glomerulosclerosis, 6(10.3%) chronic interstitial nephritis,4(6.9%) minimal chronic damage, 4(6.9%) arterionephrosclerosis, 3(5.2%) FSGS (cellular variant) and 1(1.7%) BK-virus nephropathy.
Conclusion
Although HIVAN remains the predominant histology finding in HIV-infected patients with CKD, its prevalence in this study is less than previous reports emphasizing the need for kidney biopsy for accurate diagnosis of CKD in HIV-infected patients.
Funding
- Private Foundation Support