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Kidney Week

Abstract: TH-PO231

Patient-Reported Quality of Life in Dialysis Compared with Non-Dialysis CKD Patients with Hyperkalemia in the United States and European Union 5: Results from the KDQOL

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis


  • Tafesse, Eskinder, AstraZeneca, Gaithersburg, Maryland, United States
  • Jackson, James, Adelphi Real World, Macclesfield, United Kingdom
  • Moon, Rebecca, Adelphi Real World, Macclesfield, United Kingdom
  • Milligan, Gary R., Adelphi Real World, Macclesfield, United Kingdom
  • Kim, Jennifer, AstraZeneca, Gaithersburg, Maryland, United States

Patients with chronic kidney disease (CKD) have an increased risk of hyperkalemia (HK), which increases with CKD progression. Patients on hemodialysis report negative impact to quality of life (QoL), though evidence is limited. The increased risk of HK and associated morbidity and mortality may further add to patient burden.


Data from the 2015 and 2018 Adelphi CKD Disease Specific Programmes were pooled to create a cross-sectional dataset of patients, including data from physicians and their CKD patients across France, Germany, Italy, Spain, the UK and USA. Patients completed the KDQOL, a measure targeted at specific concerns of individuals with CKD. A multiple linear regression was performed, for each of the 5 KDQOL domains, to study the association between non-dialysis dependent (NDD) patients with HK (K+ >5.0 mmol/L), DD patients without HK (K+ 3.5-5.0 mmol/L) and DD patients with HK to a reference group of NDD patients without HK (and their interaction), adjusting for age, sex, eGFR level, and presence of heart failure and diabetes.


Results from 1,242 patients showed an incremental decrease in QoL across each patient group for 2 of the 5 KDQOL domains. When compared to the reference group, NDD patients with HK experienced significantly poorer QoL across all 5 of the KDQOL domains. However, DD patients with HK experienced an additional significant deterioration in QoL across 4 of the 5 domains, compared with NDD patients without HK (Table 1).


This study highlights the negative impact that HK contributes to CKD patients, leading to further decrements in QoL, particularly among DD CKD patients. Innovative HK treatment approaches should be an important consideration by physicians to contribute to improved QoL in this patient population.

Table 1: KDQOL values vs. CKD and Hyperkalemia Status
KDQOL domains, mean (n)NDD without HKNDD with HKDD without HKDD with HK
Burden of kidney disease62.44 (774)57.61 (178); p=0.03044.78 (190); p=<0.00146.96 (100); p=<0.001
Symptoms/problems83.67 (760)80.03 (177); p=0.01278.60 (188); p=0.00576.77 (101); p=0.002
Effect of kidney disease78.42 (759)69.68 (174); p=<0.00168.29 (186); p=<0.00161.26 (100); p=<0.001
SF-12 physical summary score41.81 (741)39.37 (171); p=0.00238.30 (178); p=<0.00138.39 (98); p=0.005
SF-12 mental summary score47.42 (741)45.53 (171); p=0.02545.33 (178); p=0.05045.85 (98); p=0.020

lower scores represent poorer quality of life; p-values show the comparison to the reference group


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