Abstract: TH-PO1055
Trends of Infection Among Hospitalized Patients with Chronic Glomerulonephritis: A Retrospective Study Spanning 18 Years from a Single Tertiary Hospital
Session Information
- Glomerular Diseases: Epidemiology, Mechanisms, Complications, Outcomes
November 07, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1203 Glomerular Diseases: Clinical, Outcomes, and Trials
Authors
- Fan, Xiaohong, Division of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, BEIJING, China
- Li, Hang, Division of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, BEIJING, China
- Li, Xuemei, Division of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, BEIJING, China
- Li, Xuewang, Division of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, BEIJING, China
- Cai, Jianfang, Division of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, BEIJING, China
Background
Infection is one of the most important complications in patients with chronic glomerulonephritis. It confers an additional risk of death. However, its trends over the years in patients with chronic glomerulonephritis have seldom been demonstrated.
Methods
We conducted a retrospective analysis using the database of hospitalization to estimate current trends in different infectious diseases among hospitalized patients with chronic glomerulonephritis in Peking Union Medical College Hospital, China from 2000 through 2017. The tenth revision from the International Classification of Diseases (ICD-10) codes of discharge diagnosis was used to identify infectious diseases and different kinds of glomerulonephritis. The diagnosis of glomerulonephritis was further validated by data from our renal pathology reporting system. Cochran-Armitage trend test was used for analysis.
Results
Between 2000 and 2017, there were 18,307 hospitalizations with glomerulonephritis. Their mean age at admission was 51.7±19.8 years and 52.8% were males. The overall prevalence of infection among patients with chronic glomerulonephritis was 21.2%. The annual prevalence of overall infection increased from 14.9% in 2000 to 32.0% in 2017 (p for trend <0.001). The annual prevalence of bacteria, virus, and fungi infection, and opportunistic infection increased from 2000 to 2017, however, that of tuberculosis remained stable [figure A]. Over the years, the prevalence of respiratory tract infection, septicemia, and intracranial infection increased steadily(p for trend <0.001)，in contrast, that of gastrointestinal infection stayed unchanged(p=0.49) [figure B].
Conclusion
There had been an increasing prevalence of infection was increasing in patients with chronic glomerulonephritis over the years fro 2000 to 2017, except that of tuberculosis and gastrointestinal infection.