ASN's Mission

ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on Twitter

Kidney Week

Abstract: TH-PO1055

Trends of Infection Among Hospitalized Patients with Chronic Glomerulonephritis: A Retrospective Study Spanning 18 Years from a Single Tertiary Hospital

Session Information

Category: Glomerular Diseases

  • 1203 Glomerular Diseases: Clinical, Outcomes, and Trials

Authors

  • Fan, Xiaohong, Division of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, BEIJING, China
  • Li, Hang, Division of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, BEIJING, China
  • Li, Xuemei, Division of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, BEIJING, China
  • Li, Xuewang, Division of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, BEIJING, China
  • Cai, Jianfang, Division of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, BEIJING, China
Background

Infection is one of the most important complications in patients with chronic glomerulonephritis. It confers an additional risk of death. However, its trends over the years in patients with chronic glomerulonephritis have seldom been demonstrated.

Methods

We conducted a retrospective analysis using the database of hospitalization to estimate current trends in different infectious diseases among hospitalized patients with chronic glomerulonephritis in Peking Union Medical College Hospital, China from 2000 through 2017. The tenth revision from the International Classification of Diseases (ICD-10) codes of discharge diagnosis was used to identify infectious diseases and different kinds of glomerulonephritis. The diagnosis of glomerulonephritis was further validated by data from our renal pathology reporting system. Cochran-Armitage trend test was used for analysis.

Results

Between 2000 and 2017, there were 18,307 hospitalizations with glomerulonephritis. Their mean age at admission was 51.7±19.8 years and 52.8% were males. The overall prevalence of infection among patients with chronic glomerulonephritis was 21.2%. The annual prevalence of overall infection increased from 14.9% in 2000 to 32.0% in 2017 (p for trend <0.001). The annual prevalence of bacteria, virus, and fungi infection, and opportunistic infection increased from 2000 to 2017, however, that of tuberculosis remained stable [figure A]. Over the years, the prevalence of respiratory tract infection, septicemia, and intracranial infection increased steadily(p for trend <0.001),in contrast, that of gastrointestinal infection stayed unchanged(p=0.49) [figure B].

Conclusion

There had been an increasing prevalence of infection was increasing in patients with chronic glomerulonephritis over the years fro 2000 to 2017, except that of tuberculosis and gastrointestinal infection.